This compound is hydrophilic rather than lipophilic and demonstrates low cell permeability. Please see the link below to review a publication that may be of interest:
https://pubmed.ncbi.nlm.nih.gov/7955780/#:~:text=The%20hydrophilic%20nature%20of%20pravastatin,cross%20the%20blood%2Dbrain%20barrier.
P4498
Pravastatin sodium salt hydrate
≥98% (HPLC), powder
Synonym(s):
(βR, δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β, δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic acid sodium hydrate, Eptastatin sodium salt hydrate
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25 MG
$90.53
About This Item
Empirical Formula (Hill Notation):
C23H35O7Na · xH2O
CAS Number:
Molecular Weight:
446.51 (anhydrous basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
biological source
synthetic (organic)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white
mp
171.2-173 °C
solubility
H2O: >10 mg/mL
originator
Bristol-Myers Squibb
storage temp.
2-8°C
SMILES string
[Na+].[H][C@@](O)(CC[C@H]1[C@@H](C)C=CC2=C[C@@H](O)C[C@H](OC(=O)[C@@H](C)CC)[C@]12[H])C[C@@H](O)CC([O-])=O
InChI
1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28);/q;+1/p-1/t13-,14-,16+,17+,18+,19-,20-,22-;/m0./s1
InChI key
VWBQYTRBTXKKOG-IYNICTALSA-M
Gene Information
human ... HMGCR(3156)
General description
Pravastatin sodium is an orally effective hypocholesterolaemic agent which is structurally similar to lovastatin and compactin.[1]
Application
Pravastatin sodium salt hydrate has been used in the enzymatic method to measure mevalonic acid in serum.[2]
Biochem/physiol Actions
Pravastatin sodium is a competitive, water-soluble 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.[1]
Competitive, water-soluble 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Inhibits cholesterol synthesis in vivo (Ki ~1 nM).
Features and Benefits
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Articles
Cholesterol synthesis regulation by dietary levels, LDL receptors control lipid-rich LDL particle transport in cells.
Discover Bioactive Small Molecules for Lipid Signaling Research
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Is the Pravastatin sodium salt hydrate (Cat No.- P4498) cell permeable?
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