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P3030

Sigma-Aldrich

[Nle8,18, Tyr34]-PTH Fragment 3-34 amide bovine

≥97% (HPLC)

Synonym(s):

Ser-Glu-Ile-Gln-Phe-Nle-His-Asn-Leu-Gly-Lys-His-Leu-Ser-Ser-Nle-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Tyr-NH2

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About This Item

Empirical Formula (Hill Notation):
C177H279N53O48
CAS Number:
Molecular Weight:
3917.44
MDL number:
UNSPSC Code:
12352200

assay

≥97% (HPLC)

composition

Peptide content, ~70%

storage temp.

−20°C

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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G V Segre et al.
Endocrinology, 116(3), 1024-1029 (1985-03-01)
A potent competitive inhibitor of PTH-stimulated biological responses in vitro, [Nle8,Nle18,Tyr34] bovine PTH (bPTH)-(3-34)amide, was evaluated in vivo in dogs. These studies confirm observations in vitro, suggesting that positions 1 and 2 of the peptide are critical to its biological
K J Martin et al.
Endocrinology, 109(3), 956-959 (1981-09-01)
Recent studies suggest that the uptake of immunoreactive parathyroid hormone (iPTH) displays different characteristics in liver, kidney, and bone. Using the isolated perfused canine bone, we have characterized the uptake of two synthetic analogs of PTH, bovine PTH-(3-34) [bPTH-3(3-34)] and
R Rizzoli et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 4(6), 839-844 (1989-12-01)
Cultured Leydig tumor cells produce a parathyroid hormone (PTH)-like activity, but little is known about the regulation of the release of this factor. In the present work, we investigated the influence of the extracellular calcium concentration on the production of
R Muff et al.
Peptides, 11(5), 945-949 (1990-09-01)
Bovine parathyroid hormone (PTH) 1-34 [bPTH(1-34)] and human PTH related protein [hPTHrP(1-34)] stimulated cAMP accumulation in opossum kidney (OK) cells with Km of 5 x 10(-9) M, but inhibition of phosphate uptake was obtained with 17-fold lower Km of 3
A E Broadus et al.
Endocrinology, 117(4), 1661-1666 (1985-10-01)
Previous studies have provided evidence that tumors associated with humoral hypercalcemia of malignancy produce a factor that shares certain biological properties with, but is not, native PTH. In the present study, media from Xenopus oocytes microinjected with polyadenylated RNA prepared

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