Skip to Content
MilliporeSigma
All Photos(5)

Key Documents

View All Documentation

P2658

Sigma-Aldrich

Poly-L-lysine hydrochloride

suitable for cell culture, Mol wt 15,000-30,000

Synonym(s):

L-Lysine hydrochloride homopolymer

Sign Into View Organizational & Contract Pricing
All Photos(5)

About This Item

CAS Number:
26124-78-7
MDL number:
MFCD00081870
UNSPSC Code:
12352209
eCl@ss:
32160406
NACRES:
NA.26

product name

Poly-L-lysine hydrochloride, mol wt 15,000-30,000

form

powder or solid

Quality Level

200

mol wt

15,000-30,000

technique(s)

cell culture | mammalian: suitable

color

white to light yellow

application(s)

cell analysis

storage temp.

−20°C

Looking for similar products? Visit Product Comparison Guide

Application

Poly-L-lysine hydrochloride has been used to coat glass slides and coverslips to facilitate cell attachment.
Poly-lysine with mol. wt. >70,000 is useful in promoting cell adhesion to solid substrates.

Biochem/physiol Actions

L-Lysine is believed to prevent osteoporosis of bones, which is a characteristics of vascular calcification. Glutaric aciduria type I and pyridoxine-dependent epilepsy occurs due to lack of L-lysine catabolic pathway. Lysine participates in the regulation of NO (nitric oxide) synthesis. It possesses antiviral activity, therefore it is used in the treatment of Herpes simplex. L-Lysine is associated with a number of biochemical reactions such as acetylation, O-linked glycosylation, ubiquitination and protein methylation. Poly-L-lysine is considered as a biocompatible polymer and serves for the purpose of drug delivery across cell membrane. It is useful as one of the nanosized contrast agents in MRI (magnetic resonance imaging).

Analysis Note

Molecular weight based on viscosity.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Archishman Ghosh et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(39), 19474-19483 (2019-09-12)
Membraneless organelles, corresponding to the droplet phase upon liquid-liquid phase separation (LLPS) of protein or protein-RNA mixtures, mediate myriad cellular functions. Cells use a variety of biochemical signals such as expression level and posttranslational modification to regulate droplet formation and
Mahesh Sahare et al.
Reproduction, fertility, and development, 28(12), 2039-2050 (2015-07-17)
Spermatogonial stem cells (SSCs) are unipotent in nature, but mouse SSCs acquire pluripotency under the appropriate culture conditions. Although culture systems are available for rodent and human germ-cell lines, no proven culture system is yet available for livestock species. Here
The role of signaling pathways on proliferation and self-renewal of cultured bovine primitive germ cells
Sahare Mahesh
Reproductive medicine and biology, 14(1) (2015)
Primary culture of neural precursors from the ovine central nervous system (CNS)
A. H. Duitozz and T. Hevor
Journal of Neuroscience Methods, 131-140 (2001)
Multi-technique characterization of poly-L-lysine dendrigrafts-Cu(II) complexes for biocatalysis.
Rossi JC
Macromolecular Bioscience, 15(2), 275-290 (2015)
View All Related Papers

Articles

Layer-by-Layer (LbL) Assembly, A "Gentle Yet Flexible" Method Toward Functional Biomaterials

Recently, layer-by-layer (LbL) assembly has emerged as a versatile, gentle and, simple method for immobilization of functional molecules in an easily controllable thin film morphology.1,2 In this short review, we introduce recent advances in functional systems fabricated by using the mild, yet adaptable LbL technique.

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service