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P2303

Protein Kinase C fragment 530-558

Name: Protein Kinase C fragment 530-558
Brand: SIGMA

≥97% (HPLC), powder

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About This Item

Empirical Formula (Hill Notation):

C₁₄₈H₂₂₁N₃₅O₅₀S₂

CAS Number:

122613-29-0

Molecular Weight:

3354.67

MDL number:

MFCD00133793

UNSPSC Code:

12352200

assay

≥97% (HPLC)

form

powder

color

white

UniProt accession no.

P17252

Storage temp.

−20°C

SMILES string

CCC(C)C(NC(=O)C(CO)NC(=O)C(CCC(N)=O)NC(=O)C(Cc1ccccc1)NC(=O)C(CC(C)C)NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)C(Cc2ccccc2)NC(=O)C3CCCN3C(=O)C(C)NC(=O)C(CCC(N)=O)NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCSC)NC(=O)C(CCC(O)=O)NC(=O)C(Cc4ccc(O)cc4)NC(=O)C(CC(C)C)NC(=O)C(N)CC(C)C)C(=O)NC(CCSC)C(=O)NC(CCC(O)=O)C(=O)NC(Cc5cnc[nH]5)C(=O)NC(CC(N)=O)C(=O)NC(C(C)C)C(N)=O

Gene Information

human ... PRKCA(5578)

Amino Acid Sequence

Leu-Leu-Tyr-Glu-Met-Leu-Ala-Gly-Gln-Ala-Pro-Phe-Glu-Gly-Glu-Asp-Glu-Asp-Glu-Leu-Phe-Gln-Ser-Ile-Met-Glu-His-Asn-Val-NH₂

Biochem/physiol Actions

Part of the catalytic domain of protein kinase C and a potent activator of the enzyme.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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A synthetic peptide analog of the putative substrate-binding motif activates protein kinase C.

C House et al.

FEBS letters, 249(2), 243-247 (1989-06-05)

A 29-residue synthetic peptide, Leu530-Leu-Tyr-Glu-Met-Leu-Ala-Gly-Gln-Ala-Pro-Phe-Glu-Gly-Glu-Asp -Glu-Asp- Glu-Leu-Phe-Gln-Ser-Ile-Met-Glu-His-Asn-Val-NH2(558), corresponding to part of the catalytic domain of protein kinase C, is a potent activator of the enzyme, with a Ka of approx. 10 microM. Activation was 59 +/- 4% of that observed

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