The lab has not validated the product for use in animal studies. For the injection of 5-Pregnen-3β-ol-20-one-16α-carbonitrile using a vehicle solution, a publication suggests that 5% dimethyl sulfoxide in safflower oil may be effective. This finding was published in the Journal of Nuclear Medicine, July 2020 issue, Volume 61, Issue 7, on pages 1050-1057. The publication, titled "Imaging P-Glycoprotein Induction at the Blood-Brain Barrier of a β-Amyloidosis Mouse Model with 11C-Metoclopramide PET," is indexed with PMID: 31806767.
P0543
5-Pregnen-3β-ol-20-one-16α-carbonitrile
≥97%
Synonym(s):
Pregnenolone-16α-carbonitrile
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50 MG
$81.51
100 MG
$154.00
250 MG
$298.00
About This Item
Empirical Formula (Hill Notation):
C22H31NO2
CAS Number:
Molecular Weight:
341.49
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
$81.51
List Price$85.80Web-Only Promotion
Available to ship onApril 24, 2025Details
Request a Bulk Order
Recommended Products
biological source
synthetic (organic)
Quality Level
sterility
non-sterile
assay
≥97%
form
powder, crystals or chunks
technique(s)
cell culture | mammalian: suitable
solubility
chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow (with heat)
shipped in
ambient
storage temp.
2-8°C
SMILES string
C[C@@]12[C@](C[C@@H](C#N)[C@@H]2C(C)=O)([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC1
InChI
1S/C22H31NO2/c1-13(24)20-14(12-23)10-19-17-5-4-15-11-16(25)6-8-21(15,2)18(17)7-9-22(19,20)3/h4,14,16-20,25H,5-11H2,1-3H3/t14-,16-,17+,18-,19-,20-,21-,22-/m0/s1
InChI key
VSBHRRMYCDQLJF-ZDNYCOCVSA-N
Application
Biochem/physiol Actions
Pregnenolone-16a-carbonitrile (PCN) is a glucocorticoid receptor antagonist and a PXR (pregnane X receptor) activator.[3]
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
>199.9 °F - closed cup
flash_point_c
> 93.3 °C - closed cup
ppe
Eyeshields, Gloves, type N95 (US)
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Cytochrome P450 (CYP)3A is the most abundant CYP enzyme in the human liver, and a functional impairment of this enzyme leads to unanticipated adverse reactions and therapeutic failures; these reactions result in the early termination of drug development or the
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What delivery solvent is recommended for IP injection of 5-Pregnen-3β-ol-20-one-16α-carbonitrile into mice?
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