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O9505

Sigma-Aldrich

Orotidine

≥90% (HPLC)

Synonym(s):

Uridine-6-carboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C10H12N2O8
CAS Number:
314-50-1
Molecular Weight:
288.21
MDL number:
MFCD00057418
UNSPSC Code:
41106305
PubChem Substance ID:
329818941

assay

≥90% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless to light yellow

storage temp.

−20°C

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C(=O)NC(=O)C=C2C(O)=O

InChI

1S/C10H12N2O8/c13-2-4-6(15)7(16)8(20-4)12-3(9(17)18)1-5(14)11-10(12)19/h1,4,6-8,13,15-16H,2H2,(H,17,18)(H,11,14,19)/t4-,6-,7-,8-/m1/s1

InChI key

FKCRAVPPBFWEJD-XVFCMESISA-N

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Application

Orotidine, a nucleoside found naturally in fungi, bacteria and plants, may be used as a reference for the determination of presence of orotidine in urine or plasma due to urea cycle-related (transamidation) metabolic deficiencies or diseases.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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H Horiuchi et al.
Life sciences, 66(21), 2051-2070 (2000-05-24)
We investigated the relationship between the toxic effect of allopurinol and pyrimidine metabolism in mice. Allopurinol-induced increases in plasma transaminase levels in dinitrofluorobenzene (DNFB)-sensitized mice were not affected by uridine. In contrast, plasma creatinine and BUN tended to decrease 18
A B Burlina et al.
Journal of inherited metabolic disease, 15(5), 707-712 (1992-01-01)
The allopurinol challenge test was performed on 44 healthy subjects (28 children and 16 adolescents) in order to establish normal values of urinary orotic acid excretion following allopurinol ingestion in the paediatric population. The subjects were divided into three groups
H Nagasaka et al.
The Journal of pediatrics, 138(3), 432-434 (2001-03-10)
A liver transplantation from an asymptomatic mother, who was a carrier of ornithine transcarbamylase deficiency, to her daughter, who had severe manifestation, was successfully performed. One-year monitoring of plasma amino acid and urinary orotate/orotidine levels revealed no abnormality in the
M A Carducci et al.
In vivo (Athens, Greece), 12(3), 271-274 (1998-08-26)
Allopurinol induced pyrimidinuria is a sensitive and specific test that identifies the increased de novo pyrimidine mononucleotide biosynthesis accompanying ornithine trans carbamylase deficiency. We hypothesize that the increased de novo DNA synthesis characteristic of malignant tumors can be detected using
Meena K Purohit et al.
Journal of medicinal chemistry, 55(22), 9988-9997 (2012-09-21)
Orotidine-5'-monophosphate decarboxylase (ODCase) is an interesting enzyme with an unusual catalytic activity and a potential drug target in Plasmodium falciparum, which causes malaria. ODCase has been shown to exhibit unusual and interesting interactions with a variety of nucleotide ligands. Cytidine-5'-monophosphate
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