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About This Item
Empirical Formula (Hill Notation):
C39H61N11O12S2
CAS Number:
Molecular Weight:
940.10
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
CCC(C)C1NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(N)CSSCC(NC(=O)C(CC(N)=O)NC(=O)C(NC1=O)C(C)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(N)=O
Amino Acid Sequence
Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2 [Disulfide Bridge: 1-6]
Biochem/physiol Actions
Neuropeptide synthesized in the hypothalamus and involved in the control of lactation and parturition; selective ligand for central and peripheral oxytocin receptors.
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Anissa Benoussaidh et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 287(2), R446-R453 (2004-03-27)
The rat uterus receives an innervation from the lumbosacral and thoracolumbar segments of the spinal cord. These segments receive descending oxytocinergic projections from the paraventricular nucleus of the hypothalamus. We tested the hypothesis that oxytocin regulates uterine motility through a
M Oz et al.
Journal of neurophysiology, 86(3), 1202-1210 (2001-09-06)
Prominent arginine-vasopressin (AVP) binding and AVP V(1) type receptors are expressed early in the developing rat spinal cord. We sought to characterize their influence on neural excitability by using patch-clamp techniques to record AVP-induced responses from a population of motoneurons
Central effects of oxytocin.
P Richard et al.
Physiological reviews, 71(2), 331-370 (1991-04-01)
M A Petty et al.
European journal of pharmacology, 112(2), 203-210 (1985-06-07)
In conscious, chronically instrumented normotensive male Wistar rats intravenous (i.v.) administration of oxytocin (OXT) (greater than or equal to 100 ng) induced a dose-related biphasic change in mean arterial pressure (MAP). This consisted of an initial pressor effect accompanied by
G C Harris et al.
The Journal of endocrinology, 156(1), 35-42 (1998-03-13)
Oxytocin (OT) is present in the mammalian testis and has been postulated to play a role in modulation of seminiferous tubule contractility. However, recent evidence suggests that the myoid cells responsible for such contractile activity do not express OT receptors.
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