O3011
Oxiracetam
Synonym(s):
4-Hydroxy-2-oxopyrrolidine-N-acetamide
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About This Item
Empirical Formula (Hill Notation):
C6H10N2O3
CAS Number:
Molecular Weight:
158.16
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Recommended Products
storage temp.
2-8°C
SMILES string
NC(=O)CN1CC(O)CC1=O
InChI
1S/C6H10N2O3/c7-5(10)3-8-2-4(9)1-6(8)11/h4,9H,1-3H2,(H2,7,10)
InChI key
IHLAQQPQKRMGSS-UHFFFAOYSA-N
Biochem/physiol Actions
Nootropic agent, improves learning and memory, and prevents impairment of cognitive functions. Its mechanism of action in not yet known, but it is suggested to modulate glutamatergic and cholinergic neurotransmission. Protein kinase C may be involved.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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X L Jiao et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 29(8), 570-575 (1994-01-01)
A method was developed for the determination of oxiracetam concentration in serum and urine by HPLC. Acyclovir was used as an internal standard. The analytical column was a stainless-steel column (30 mm x 4.6 mm ID) filled with 10 microns
Y Lu et al.
Brain research, 768(1-2), 197-207 (1997-11-22)
Previous studies demonstrated that DBA/2J (DBA) mice performed poorly while C57BL/6J (C57) mice performed normally on a number of complex learning and memory tasks. Chronic oxiracetam treatment dramatically improved the performance of DBA mice but not that of C57 mice
A Pittaluga et al.
European journal of pharmacology, 272(2-3), 203-209 (1995-01-16)
Oxiracetam, aniracetam and D-cycloserine, three putative cognition enhancers, were examined in a functional assay for NMDA receptors. Rat hippocampal slices or synaptosomes were labeled with [3H]noradrenaline and exposed to NMDA or glutamate in superfusion. NMDA (100 microM) elicited a remarkable
C Mondadori et al.
Behavioural brain research, 77(1-2), 223-225 (1996-05-01)
The memory-enhancing effects of a single treatment with the GABAB antagonist CGP 36,742 (10 mg/kg) or the nootropic agent oxiracetam (100 mg/kg) given immediately after a learning experience ('post-trial') remain detectable for at least 4 months thereafter. This indicates that
Chenhao Zhang et al.
Neuropsychiatric disease and treatment, 15, 1639-1647 (2019-07-13)
Objective: To explore the efficacy and safety of "cocktail therapy" in Parkinson's disease with dementia (PDD). Patients and methods: Sixty patients with PDD were randomly assigned to the test group (n=30) and a control group (n=30). The control group received
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