N8648
GR 231118
≥95% (HPLC), lyophilized powder
Synonym(s):
1229U91, Ile-Glu-Pro-Dapa-Tyr-Arg-Leu-Arg-Tyr-NH2, cyclic (2,4′)(2′,4) diamide, Neuropeptide Y Antagonist
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About This Item
MDL number:
UNSPSC Code:
12352200
assay
≥95% (HPLC)
form
lyophilized powder
mol wt
calculated mol wt 2353
storage temp.
−20°C
Gene Information
human ... NPY1R(4886)
mouse ... NPY1R(29358)
rat ... NPY1R(18166)
Amino Acid Sequence
Ile-Glu-Pro-Dapa-Tyr-Arg-Leu-Arg-Tyr-NH2
Biochem/physiol Actions
High affinity and selective NPY Y1 receptor antagonist.
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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J A Angus
Clinical and experimental pharmacology & physiology, 24(5), 297-304 (1997-05-01)
1. The present review covers two aspects of the author's research into the pharmacology of vascular reactivity of isolated vessels and in the intact circulation. First, how 'normal' reactivity is altered by injury or disease and, second, how novel drugs
B Kennedy et al.
The Journal of pharmacology and experimental therapeutics, 281(1), 291-296 (1997-04-01)
Neuropeptide Y (NPY) is a potent pressor agent that is stored in the sympathetic nerves. In several species, NPY release is augmented when sympathetic impulse frequencies increase. We investigated the extent to which NPY contributes to the pressor response to
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