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N6909

Neurturin human

Name: Neurturin human
Brand: SIGMA

>95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonym(s):

NRTN, NTN

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About This Item

MDL number:

MFCD01867712

UNSPSC Code:

51111800

biological source

human

recombinant

expressed in E. coli

assay

>95% (SDS-PAGE)

form

lyophilized powder

potency

15-50 ng/mL ED₅₀

mol wt

monomer calculated mol wt ~12.5 kDa
predicted mol wt ~14 kDa by SDS-PAGE (reducing)

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

impurities

endotoxin, tested

UniProt accession no.

Q99748

storage temp.

−20°C

Gene Information

human ... NRTN(4902)

Biochem/physiol Actions

Member of the glial cell line-derived neurotrophic factor family of ligands. Exerts potent effects on the function and survival of central and peripheral neurons. Activates the RET receptor tyrosine kinase, MAP kinase, and phosphatidylinositol 3-kinase pathways. Human and mouse NTN share 91% sequence identity.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg bovine serum albumin.

Analysis Note

The biological activity is measured by its ability to bind recombinant human GFRα2/Fc.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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