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N6144

Sigma-Aldrich

[Ala5, β-Ala8]-α-Neurokinin Fragment 4-10

≥97% (HPLC)

Synonym(s):

Asp-Ala-Phe-Val-β-Ala-Leu-Met-NH2

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About This Item

Empirical Formula (Hill Notation):
C35H56N8O9S
CAS Number:
127633-71-0
Molecular Weight:
764.93
MDL number:
MFCD00133057
UNSPSC Code:
12352200
PubChem Substance ID:
24897773

assay

≥97% (HPLC)

UniProt accession no.

P20366

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(CC(C)C)NC(=O)CCNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(C)NC(=O)C(N)CC(O)=O)C(C)C)C(N)=O

InChI

1S/C35H56N8O9S/c1-19(2)16-25(33(50)41-24(30(37)47)13-15-53-6)40-27(44)12-14-38-35(52)29(20(3)4)43-34(51)26(17-22-10-8-7-9-11-22)42-31(48)21(5)39-32(49)23(36)18-28(45)46/h7-11,19-21,23-26,29H,12-18,36H2,1-6H3,(H2,37,47)(H,38,52)(H,39,49)(H,40,44)(H,41,50)(H,42,48)(H,43,51)(H,45,46)

InChI key

AEABSNNHNNJKEX-UHFFFAOYSA-N

Gene Information

human ... TAC1(6863)

Amino Acid Sequence

Asp-Ala-Phe-Val-β-Ala-Leu-Met-NH2

Biochem/physiol Actions

NK-2 tachykinin receptor agonist.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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T Soejima et al.
Archives of oral biology, 44(6), 455-463 (1999-07-13)
Both substance P and neurokinin A are known as neurotransmitters of the submandibular ganglion cell. In this study, the effects of neurokinin (NK) receptor-subtype agonists on hamster submandibular ganglion cells were investigated using the whole-cell patch-clamp technique. Membrane currents evoked
S Evangelista et al.
Peptides, 11(2), 293-297 (1990-03-01)
We have developed a novel series of peptides, related to the NKA(4-10) sequence, in which substitution of selected amino acids determined variations in the affinity for the TK receptor subtypes. Subcutaneous pretreatment of rats with some peptides of this series

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