assay
>98%
form
lyophilized powder
storage temp.
−20°C
Amino Acid Sequence
Thr-Glu-Pro-Gly-Leu-Glu-Glu-Val-Gly-Glu-Ile-Glu-Gln-Lys-Gln-Leu-Gln
Biochem/physiol Actions
Endogenous 17 amino acid peptide from the orphanin FQ precursor, prepronociceptin/orphanin FQ, that does not bind to ORL1 receptors but is a functional antagonist of orphaninFQ/nociceptin.
Endogenous 17 amino acid peptide from the orphanin FQ precursor; does not bind to ORL1 receptors; functional antagonist of orphaninFQ/nociceptin.
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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E Okuda-Ashitaka et al.
Peptides, 21(7), 1101-1109 (2000-09-22)
We identified a novel neuropeptide and named it "nocistatin." Its presence was expected by analysis of the precursor for the neuropeptide nociceptin or orphanin FQ (Noc/OFQ), previously identified as an endogenous ligand for the orphan opioid receptor-like receptor. The precursor
H U Zeilhofer et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(13), 4922-4929 (2000-06-24)
Nociceptin/orphanin FQ (N/OFQ) and nocistatin (NST) are two recently identified neuropeptides with opposing effects on several CNS functions, including spinal nociception. The cellular mechanisms that underlie this antagonism are not known. Here, we have investigated the effects of both peptides
E Okuda-Ashitaka et al.
Nature, 392(6673), 286-289 (1998-04-01)
Prolonged tissue damage or injury often leads to chronic pain states such that noxious stimuli evoke hyperalgesia and innocuous tactile stimuli evoke pain (allodynia). The neuropeptide nociceptin, also known as orphanin FQ, is an endogenous ligand for the orphan opioid-like
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