Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

M9503

Sigma-Aldrich

DL-Methionine DL-sulfoximine

Synonym(s):

DL-(3-Amino-3-carboxypropyl) methyl sulfoximine

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C5H12N2O3S
CAS Number:
Molecular Weight:
180.23
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

storage temp.

2-8°C

SMILES string

CS(=N)(=O)CCC(N)C(O)=O

InChI

1S/C5H12N2O3S/c1-11(7,10)3-2-4(6)5(8)9/h4,7H,2-3,6H2,1H3,(H,8,9)

InChI key

SXTAYKAGBXMACB-UHFFFAOYSA-N

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Edgar L Perez et al.
Neurobiology of disease, 47(3), 331-337 (2012-06-05)
Increased extracellular brain glutamate has been implicated in the pathophysiology of human refractory temporal lobe epilepsy (TLE), but the cause of the excessive glutamate is unknown. Prior studies by us and others have shown that the glutamate degrading enzyme glutamine
Saverio Tardito et al.
Amino acids, 42(6), 2507-2512 (2011-07-20)
L-Methionine sulfoximine (MSO) and DL-Phosphinothricin (PPT), two non-proteinogenic amino acids known as inhibitors of Glutamine Synthetase, cause a dose-dependent increase in the phosphorylation of the mTOR substrate S6 kinase 1. The effect is particularly evident in glutamine-depleted cells, where mTOR
Isabelle Georis et al.
The Journal of biological chemistry, 286(52), 44897-44912 (2011-11-01)
Nitrogen availability regulates the transcription of genes required to degrade non-preferentially utilized nitrogen sources by governing the localization and function of transcription activators, Gln3 and Gat1. TorC1 inhibitor, rapamycin (Rap), and glutamine synthetase inhibitor, methionine sulfoximine (Msx), elicit responses grossly
Vishal Mahajan et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 17(22), 6187-6195 (2011-04-20)
A synthesis of sulfoximine-substituted medium-ring nitrogen heterocycles (MRNHs) having a high degree of substitution has been developed. Its key steps are the modular asymmetric synthesis of sulfoximine-substituted N-tethered trienes and their Ru-catalyzed ring-closing metathesis (RCM) reaction. The highly substituted N-tethered
Jan Albrecht et al.
Biochemical pharmacology, 80(9), 1303-1308 (2010-07-27)
Ammonia is a major neurotoxin implicated in hepatic encephalopathy (HE). Here we discuss evidence that many aspects of ammonia toxicity in HE-affected brain are mediated by glutamine (Gln), synthesized in excess from ammonia and glutamate by glutamine synthetase (GS), an

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service