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M8193

MADAM dihydrochloride

Name: MADAM dihydrochloride
Brand: SIGMA

Synonym(s):

2-(2′-Amino-4′-methylphenylthio)-N,N-dimethylbenzylamine dihydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₂₂Cl₂N₂S

CAS Number:

411208-45-2

Molecular Weight:

345.33

MDL number:

MFCD07370142

UNSPSC Code:

12352202

PubChem Substance ID:

24724543

NACRES:

NA.77

form

solid

storage condition

desiccated
protect from light
under inert gas

color

white

solubility

H₂O: ~18 mg/mL

storage temp.

2-8°C

SMILES string

Cl[H].Cl[H].CN(C)Cc1ccccc1Sc2ccc(C)cc2N

InChI

1S/C16H20N2S.2ClH/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3;;/h4-10H,11,17H2,1-3H3;2*1H

InChI key

GSBZMNLLLNHKDY-UHFFFAOYSA-N

Biochem/physiol Actions

High affinity ligand for the serotonin transporter SERT

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Pharmacological characterization of N,N-dimethyl-2-(2-amino-4-methylphenyl thio)benzylamine as a ligand of the serotonin transporter with high affinity and selectivity.

Sylvie Chalon et al.

The Journal of pharmacology and experimental therapeutics, 304(1), 81-87 (2002-12-20)

Serotonin transporter has a key-role in regulation of serotoninergic function, and is involved in numerous neurodegenerative and psychiatric disorders. To obtain an efficient radioactive ligand allowing the study of this transporter in vitro and in vivo, we synthesized a new

Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation.

Patrick Emond et al.

Journal of medicinal chemistry, 45(6), 1253-1258 (2002-03-08)

A series of diphenyl sulfide derivatives substituted at the 1-, 2'-, and 4'-positions has been synthesized and evaluated for their in vitro affinities at the dopamine, serotonin (SERT), and norepinephrine transporters. The examination of K(i) values revealed that most of

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