As reported in the PROPERTIES section, this product is soluble in H2O at 50 mg/mL yielding a clear, colorless solution.
M4263
Malonyl coenzyme A lithium salt
≥90% (HPLC)
Synonym(s):
Malonyl CoA lithium salt
Sign Into View Organizational & Contract Pricing
Select a Size
5 MG
$154.00
10 MG
$295.00
25 MG
$591.00
100 MG
$1,880.00
$154.00
Available to ship onApril 29, 2025Details
All Photos(5)
Select a Size
Change View
5 MG
$154.00
10 MG
$295.00
25 MG
$591.00
100 MG
$1,880.00
About This Item
Empirical Formula (Hill Notation):
C24H38N7O19P3S · xLi+
CAS Number:
Molecular Weight:
853.58 (free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
$154.00
Available to ship onApril 29, 2025Details
Recommended Products
Quality Level
assay
≥90% (HPLC)
form
powder
solubility
H2O: soluble 50 mg/mL protein, clear, colorless
storage temp.
−20°C
SMILES string
[Li].CC(C)(COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O
InChI
1S/C24H38N7O19P3S.Li/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31;/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41);
InChI key
OPIJLICRFQMMJH-UHFFFAOYSA-N
Looking for similar products? Visit Product Comparison Guide
Related Categories
Application
Malonyl coenzyme A lithium salt has been used:
- in Krebs Ringer bicarbonate medium for preincubation of trypsinized and re-suspended fibroblast for fatty acid oxidation assay[1]
- in HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) buffer used for scintillation proximity assay for fatty acid synthase[2]
- as an internal standard in the reaction mixture used for succinyl-CoA ligase assay[3]
Biochem/physiol Actions
Coenzyme A functions as an acyl group carrier, acetyl-CoA. Malonyl Coenzyme A is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl CoA is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Malonyl-CoA is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.
Malonyl coenzyme A is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl CoA is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Metabolism of glucose also yields malonyl coenzyme A. It allosterically blocks the action of carnitine palmitoyltransferase 1, which affects the transfer of long chain fatty acids into mitochondria. Inactivation of fatty acid synthase results in excess malonyl coenzyme A which leads to anorexia.[4]
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Characterization of fatty acid synthase activity using scintillation proximity
Weiss DR and Glickman JF
Assay and Drug Development Technologies, 1(1-2), 161-166 (2003)
Succinyl-CoA synthetase (SUCLA2) deficiency in two siblings with impaired activity of other mitochondrial oxidative enzymes in skeletal muscle without mitochondrial DNA depletion
Huang X, et al.
Molecular Genetics and Metabolism, 120(3), 213-222 (2017)
Gary D Lopaschuk et al.
Pharmacological reviews, 62(2), 237-264 (2010-04-16)
The central nervous system mediates energy balance (energy intake and energy expenditure) in the body; the hypothalamus has a key role in this process. Recent evidence has demonstrated an important role for hypothalamic malonyl CoA in mediating energy balance. Malonyl
Establishing a reference interval for measurement of flux through the mitochondrial fatty acid oxidation pathway in cultured skin fibroblasts.
Srinivas B Narayan et al.
Clinical chemistry, 51(3), 644-646 (2005-03-02)
Principles of diabetes mellitus, 96-96 (2010)
Articles
Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.
-
whats the appropriate solvent? PBS? DMSO? DW?
1 answer-
Helpful?
-
-
Malonyl Coenzyme A can be store as aqueous solution ?
1 answer-
The stability of Malonyl Coenzyme A in aqueous solution has not been determined. However, other sources indicate that prepared solutions may be stable for several months at a minimum of -20 °C.
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
