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M2922

Sigma-Aldrich

3-Methyl-6-[3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine

Synonym(s):

CL 218,872

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About This Item

Empirical Formula (Hill Notation):
C13H9F3N4
CAS Number:
66548-69-4
Molecular Weight:
278.23
MDL number:
MFCD00674912
UNSPSC Code:
12352200
PubChem Substance ID:
24278545

storage temp.

2-8°C

SMILES string

Cc1nnc2ccc(nn12)-c3cccc(c3)C(F)(F)F

Gene Information

human ... BZRAP1(9256) , GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA5(2558) , GABRA6(2559) , GABRG2(2566)

Biochem/physiol Actions

Selective agonist at the BZI benzodiazepine receptor.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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J Karolak-Wojciechowska et al.
Bioorganic & medicinal chemistry, 2(8), 773-779 (1994-08-01)
Electronic parameters (molecular electrostatic potential MEP, charge distribution on the nitrogen atoms, dipole moment mu and ionization potential IP) were calculated by semiempirical quantum chemistry methods for 2 sets (X = H and m-CF3, the syn- and anti-rotamers of the
R K McNamara et al.
Epilepsy research, 16(1), 19-26 (1993-09-01)
To clarify the role of benzodiazepine receptors in kindling, the present experiment assessed the effects of CL 218,872 (1, 5, 10, and 20 mg/kg), a triazolopyridazine with a selective affinity for the putative benzodiazepine BZ1 receptor subtype, on the development
R L Hyson et al.
Journal of molecular neuroscience : MN, 8(3), 193-205 (1997-06-01)
Neurons in nucleus magnocellularis (NM) and nucleus laminaris (NL) of the chick brainstem auditory system show an unusual physiological response to GABA. Examination of these nuclei using in situ hybridization for GABAA receptor subunits showed a differential expression of the
A Hendrickson et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 12(4), 299-314 (1994-06-01)
The expression of subtypes of the GABA-A/benzodiazepine receptor complex has been studied during pre- and postnatal development of Macaca monkey visual cortex using complementary radioligand and immunocytochemical labeling. Type I benzodiazepine receptors were labeled directly by [3H]zolpidem. Type II receptors
M C Gravielle et al.
Neuroreport, 6(15), 2013-2016 (1995-10-23)
The developmental time-course of type I and type II benzodiazepine receptors in the chick optic lobe was determined using a triazolopyridazine, CL 218872. At embryonic day 13 most of the binding sites corresponded to type II (98.23%), while type I
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