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L8401

Sigma-Aldrich

LE 300

solid

Synonym(s):

7-Methyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecine

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About This Item

Empirical Formula (Hill Notation):
C20H22N2
Molecular Weight:
290.40
MDL number:
MFCD00951284
UNSPSC Code:
12352200
PubChem Substance ID:
24278519

form

solid

solubility

DMSO: 26 mg/mL
H2O: insoluble

SMILES string

CN1CCc2ccccc2Cc3[nH]c4ccccc4c3CC1

InChI

1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3

InChI key

YEWGIGCYIAMFMA-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)
rat ... Drd1a(24316)

Biochem/physiol Actions

Potent, selective D1 dopamine receptor antagonist.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
090K4704

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Anni Allikalt et al.
Journal of pharmacological and toxicological methods, 86, 81-86 (2017-04-17)
G-protein-coupled receptors have become very important drug targets and therefore ligand binding assays for these receptors are an essential part of drug discovery. Among a variety of experimental systems, the radioligand binding assay has remained as one of the main
T Witt et al.
Journal of medicinal chemistry, 43(10), 2079-2081 (2000-05-23)
Partially hydrogenated derivatives of the new heterocyclic ring systems benz[d]indolo[2,3-g]azecine and bisindolo[3,2-d][2, 3-g]azecine were synthesized starting from lactones and amines via the described synthetic methods. In binding assays with rat striatal receptors, 7-methyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2, 3-g]azecine (LE 300) proved to be of

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