L4163
[des-Gly10, D-His2, D-Trp6, Pro9]-LH-RH ethylamide trifluoroacetate salt
>98% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C64H83N17O12
Molecular Weight:
1282.45
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.32
Quality Level
assay
>98% (HPLC)
storage temp.
−20°C
Gene Information
human ... GNRH1(2796) , GNRHR(2798)
mouse ... GNRH1(14714) , GNRHR(14715)
rat ... GNRH1(25194) , GNRHR(81668)
Amino Acid Sequence
Glp-His-Trp-Ser-Tyr-Trp-Leu-Arg-Pro-NHEt
Biochem/physiol Actions
Glp-His-Trp-Ser-Tyr-Trp-Leu-Arg-Pro-NHEt ([des-Gly10, D-His2, D-Trp6, Pro9]-LH-RH) is a peptide from GnRH (gonadotropin-releasing hormone) agonists.[1] GnRH (Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), which is also referred to as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary glands.[2][3][1] Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism.[3]
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Luigi Maione et al.
PloS one, 8(7), e69616-e69616 (2013-08-13)
Normosmic congenital hypogonadotropic hypogonadism (nCHH) is a rare reproductive disease leading to lack of puberty and infertility. Loss-of-function mutations of GNRH1 gene are a very rare cause of autosomal recessive nCHH. R31C GNRH1 is the only missense mutation that affects
Indira Nederpelt et al.
British journal of pharmacology, 173(1), 128-141 (2015-09-24)
Drug-target residence time is an important, yet often overlooked, parameter in drug discovery. Multiple studies have proposed an increased residence time to be beneficial for improved drug efficacy and/or longer duration of action. Currently, there are many drugs on the
Brooke Tata et al.
PLoS biology, 12(9), e1001952-e1001952 (2014-09-24)
Characterization of the genetic defects causing gonadotropic deficiency has made a major contribution to elucidation of the fundamental role of Kisspeptins and Neurokinin B in puberty onset and reproduction. The absence of puberty may also reveal neurodevelopmental disorders caused by
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