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K1764

Sigma-Aldrich

Kazusamycin A

from Streptomyces sp., ≥95% (HPLC), aqueous methanol solution

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About This Item

Empirical Formula (Hill Notation):
C33H48O7
CAS Number:
92090-94-3
Molecular Weight:
556.73
MDL number:
MFCD03265635
UNSPSC Code:
12352200

biological source

Streptomyces sp.

assay

≥95% (HPLC)

form

aqueous methanol solution

solubility

methanol: water: soluble 7:3
DMSO: soluble
H2O: insoluble
chloroform: soluble
ethanol: soluble
hexane: insoluble
methanol: soluble

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCC(\C=C\C1OC(=O)C=CC1C)=C/C(C)C\C=C\C(C)=C\C(CO)C(=O)C(C)C(O)C(C)C\C(C)=C\C(O)=O

Biochem/physiol Actions

Kazusamycin A, an unsaturated branched chain fatty acid with a terminal lactone ring, is a hydroxy analog of Leptomycin B. It has significant in vitro cytotoxic activity against various human and mouse tumor lines encompassing a wide range of tissue types. Kazusamycin A exhibits in vivo antitumor activity against experimental murine tumors. It inhibits nuclear export and Rev translocation, a regulatory gene product in the HIV genome, at nanomolar concentrations.

Physical form

70% methanol solution.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

60.0 °F - closed cup

flash_point_c

15.56 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
035K4092

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The effect of kazusamycin on the growth of murine solid tumors and their spontaneous metastasis.
E Yoshida et al.
The Journal of antibiotics, 40(3), 391-393 (1987-03-01)
I Umezawa et al.
The Journal of antibiotics, 37(7), 706-711 (1984-07-01)
A new antibiotic kazusamycin, was isolated from the culture broth of Streptomyces sp. No. 81-484, which shows antitumor activity against experimental murine tumors. This antibiotic did not possess antibacterial activity against Gram-positive and Gram-negative bacteria, but showed strong cytotoxic activity
Wang, Y., et al.
Helvetica Chimica Acta, 80, 2157-2167 (1997)
B J Roberts et al.
Cancer chemotherapy and pharmacology, 16(2), 95-101 (1986-01-01)
CI-940, PD 114,721, and PD 118,607 are structurally novel antibiotics, which were isolated from fermentation beers of a previously unknown actinomycete. They are highly lipophilic acids characterized by unsaturated lactone and branched, polyunsaturated aliphatic side-chain moieties. All three agents demonstrated
Komiyama, K., et al.
Antibiotics, 38, 220-223 (1985)
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