I9279
Interleukin-11 from mouse
>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
Synonym(s):
IL-11
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About This Item
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biological source
mouse
Quality Level
recombinant
expressed in E. coli
assay
>97% (SDS-PAGE)
form
lyophilized powder
mol wt
predicted mol wt ~19 kDa
packaging
pkg of 5 μg
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Il11(16156)
Biochem/physiol Actions
Interleukin-11, also called adipogenesis inhibitory factor (AGIF), is a pleotropic cytokine that acts on hematopoietic progenitor cells and stromal cells. Although recombinant human IL-11 has a predicted molecular mass of 19 kDa, it migrates as a 23 kDa band in SDS-PAGE. It is a functional homolog of IL-6, inducing the proliferation of certain plasmacytoma cell lines and acute phase protein secretion in the liver. IL-11 stimulates the production of erythrocytes, megakaryocytes, and T cell development of antibody producing B cells.
Physical form
Lyophilized from a 20.0 μL of a 0.2 μm filtered solution in phosphate buffered saline, pH 7.3, with 5% trehalose and with 50 μg bovine serum albumin per 1μg as a carrier protein.
Analysis Note
Assayed in a cell proliferation assay using T11 cells, a subline of the IL-6 dependent mouse plasmacytoma cell line T1165.85.2, that has been adapted to grow in IL-11.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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J C Morris et al.
Experimental hematology, 24(12), 1369-1376 (1996-10-01)
Human interleukin-11 (IL-11) has been shown to have pleiotropic action on hematopoietic, hepatic, stromal, epithelial, neural, and osteoclast cells. In the present work, the murine IL-11 cDNA has been isolated from a fetal thymic cell line, and its structure and
Samadhi Aparicio-Siegmund et al.
Oncotarget, 5(8), 2131-2148 (2014-04-20)
The Janus kinase / signal transducer and activator of transcription (Jak/STAT) pathway can be activated by many different cytokines, among them all members of the Interleukin (IL-)6 family. Dysregulation of this pathway, resulting in its constitutive activation, is associated with
Brandon K Hadland et al.
The Journal of clinical investigation, 125(5), 2032-2045 (2015-04-14)
Hematopoietic stem cells (HSCs) first emerge during embryonic development within vessels such as the dorsal aorta of the aorta-gonad-mesonephros (AGM) region, suggesting that signals from the vascular microenvironment are critical for HSC development. Here, we demonstrated that AGM-derived endothelial cells
Carlyn A Figueiredo et al.
PloS one, 9(7), e101947-e101947 (2014-08-01)
Intravenous immunoglobulin (IVIg) has been used to treat a variety of autoimmune disorders including multiple sclerosis (MS); however its mechanism of action remains elusive. Recent work has shown that interleukin-11 (IL-11) mRNAs are upregulated by IVIg in MS patient T
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