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Key Documents

I4638

Sigma-Aldrich

Interleukin-1β Fragment 163-171 human

≥97% (HPLC), synthetic

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About This Item

Empirical Formula (Hill Notation):
C39H64N12O19
CAS Number:
106021-96-9
Molecular Weight:
1004.99
MDL number:
MFCD00076554
UNSPSC Code:
51111800
PubChem Substance ID:
329815376

biological source

synthetic

assay

≥97% (HPLC)

form

powder

mol wt

Mw 1004.99

packaging

pkg of 1 mg

color

white

solubility

water: soluble 1 mg/mL, clear, colorless

UniProt accession no.

P01584

storage temp.

−20°C

SMILES string

CC(C)[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(O)=O

InChI

1S/C39H64N12O19/c1-17(2)31(43)38(68)47-18(6-9-25(41)53)32(62)44-15-27(55)45-19(7-10-28(56)57)33(63)46-20(8-11-29(58)59)34(64)51-24(16-52)37(67)49-22(13-26(42)54)35(65)50-23(14-30(60)61)36(66)48-21(39(69)70)5-3-4-12-40/h17-24,31,52H,3-16,40,43H2,1-2H3,(H2,41,53)(H2,42,54)(H,44,62)(H,45,55)(H,46,63)(H,47,68)(H,48,66)(H,49,67)(H,50,65)(H,51,64)(H,56,57)(H,58,59)(H,60,61)(H,69,70)/t18-,19-,20-,21-,22-,23-,24-,31-/m0/s1

InChI key

NIXBZDOQHRZFDR-OEWCNXHOSA-N

Gene Information

human ... IL1B(3553)

Amino Acid Sequence

Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys

Biochem/physiol Actions

IL1B (interleukin 1 β) is an immune-activating cytokine. In presence of infection or cell stress, it gets converted into active mature form.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Xianwei Wang et al.
Apoptosis : an international journal on programmed cell death, 17(8), 908-915 (2012-04-25)
Angiotensin II (Ang II) exerts its effects by activating its receptors, primarily type 1 (AT1R) and type 2 (AT2R). While the role of AT1R activation in cardiomyocyte physiology is well known, the role of AT2R in cardiomyocyte apoptosis remains controversial.
G Antoni et al.
Journal of immunology (Baltimore, Md. : 1950), 137(10), 3201-3204 (1986-11-15)
Short peptide fragments of human and murine interleukin 1 (IL 1) were synthesized on the basis of their predicted exposure on the surface of the molecule in an attempt to identify the minimal structure responsible for the immunostimulatory activity of
Gulden Avci et al.
The Journal of surgical research, 172(1), e39-e46 (2011-11-15)
Curcumin has been shown to decrease ischemia-reperfusion (I/R) injury in kidney or brain tissues. In this study, the effects of curcumin were evaluated in skeletal muscle during I/R injury. Hind limb ischemia was induced by clamping the common femoral artery
L Nencioni et al.
Journal of immunology (Baltimore, Md. : 1950), 139(3), 800-804 (1987-08-01)
The stimulating effect of a synthetic nonapeptide (fragment 163-171) of human interleukin 1 beta (IL-1 beta) on antibody responses to both T helper-dependent and T helper-independent antigens was investigated. It was shown that the nonapeptide enhanced the antibody response, as
Anna K Blakney et al.
Journal of biomedical materials research. Part A, 100(6), 1375-1386 (2012-03-13)
Poly(ethylene glycol) (PEG) hydrogels, modified with RGD, are promising platforms for cell encapsulation and tissue engineering. While these hydrogels offer tunable mechanical properties, the extent of the host response may limit their in vivo applicability. The overall objective was to
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