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I123

Sigma-Aldrich

ICI 216,140

>95%, solid

Synonym(s):

(CH3)2CHCO-His-Trp-Ala-Val-D-Ala-His-Leu-NHCH3

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About This Item

Empirical Formula (Hill Notation):
C45H65N13O8
CAS Number:
124001-41-8
Molecular Weight:
916.08
MDL number:
MFCD00153815
UNSPSC Code:
12352200

assay

>95%

form

solid

color

white

storage temp.

−20°C

SMILES string

CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)C(C)C)C(C)C

Biochem/physiol Actions

Potent in vivo receptor antagonist of the bombesin/gastrin releasing peptide receptor.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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B J Campbell et al.
Regulatory peptides, 49(3), 249-255 (1994-01-13)
The mechanisms of action of gastrin and gastrin releasing peptide (GRP) in stimulating gastric acid secretion were examined in the anaesthetized turkey. Gastrin and GRP produced dose-dependent increases in acid secretion that were inhibited by the gastrin/CCK-B antagonist CI988. The
R R Ryan et al.
Peptides, 14(6), 1231-1235 (1993-11-01)
We examined the profile of two bombesin (BN) antagonists, (CH3)2CHCO-His-Trp-Ala-Val-D-Ala-His-Leu-NHCH3] (ICI 216140) and [D-Phe6,des-Met14]BN(6-14)ethylamide (DPDM-BN EA), against neuromedin B-induced Ca2+ mobilization in the small cell lung cancer (SCLC) line NCI-H345. Neuromedin B (NMB), a BN-like peptide sharing sequence homology with
R R Ryan et al.
European journal of pharmacology, 306(1-3), 307-314 (1996-06-13)
We examined the effect of two des-Met-bombesin analogues, [(CH3)2CHCO-His-Trp-Ala-Val-D-Ala-His-Leu-NHCH3] (ICI 216140) and [D-Phe6,des-Met14]bombesin(6-14) ethylamide (DPDM-bombesin ethylamide), on neuromedin B-induced Ca2+ and [3H]arachidonate release in BALB 3T3 cells transfected with human neuromedin B receptors. ICI 216140 and DPDM-bombesin ethylamide both stimulated
ICI 216140 and other potent in vivo antagonist analogs of bombesin/gastrin-releasing peptide.
Camble, R., et al.
Peptides: Chemistry, Structure and Biology, Proceedings of the Eleventh American Peptide Symposium, 174-174 (1989)
B Campbell et al.
The American journal of physiology, 261(1 Pt 1), G16-G21 (1991-07-01)
Endocrine cells in the acid-secreting part of the avian stomach, the proventriculus, contain two forms of gastrin-releasing peptide (GRP) of 27 and 6 residues, respectively. We have examined the actions of exogenous GRP-27 and GRP-6 and endogenously released GRP in
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