H9279
α-Hydroxyfarnesylphosphonic acid
2 mg/mL in ethanol
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About This Item
Empirical Formula (Hill Notation):
C15H27O4P
CAS Number:
Molecular Weight:
302.35
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
concentration
2 mg/mL in ethanol
storage temp.
−20°C
SMILES string
C\C(C)=C\CC\C(C)=C\CC\C(C)=C\C(O)P(O)(O)=O
Biochem/physiol Actions
Inhibitor of farnesyltransferase; much weaker activity against geranylgeranyl transferase.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2
Storage Class
3 - Flammable liquids
wgk_germany
WGK 2
flash_point_f
57.2 °F - closed cup - Solvent
flash_point_c
14.0 °C - closed cup - Solvent
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Certificates of Analysis (COA)
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J B Gibbs et al.
The Journal of biological chemistry, 268(11), 7617-7620 (1993-04-15)
The ras oncogene product, Ras, is synthesized in vivo as a precursor protein that requires post-translational processing to become biologically active and to be capable of transforming mammalian cells. Farnesylation appears to be a critical modification of Ras, and thus
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