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G0267

Sigma-Aldrich

Mini Gastrin I human

≥97% (HPLC)

Synonym(s):

HG-13

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About This Item

Empirical Formula (Hill Notation):
C74H99N15O26S
CAS Number:
60748-07-4
Molecular Weight:
1646.73
MDL number:
MFCD00133359
UNSPSC Code:
12352200

assay

≥97% (HPLC)

UniProt accession no.

P01350

storage temp.

−20°C

SMILES string

CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O

Gene Information

human ... GAST(2520)

Amino Acid Sequence

Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2

Biochem/physiol Actions

CCKB/gastrin receptor agonist. Corresponds to fragment 5-17 of human gastrin I. This form of gastrin has been isolated from tumor tissue.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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Elisabeth von Guggenberg et al.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 14(3), 366-375 (2011-07-07)
Targeting of cholecystokinin receptor expressing malignancies such as medullary thyroid carcinoma is currently limited by low in vivo stability of radioligands. To increase the stability, we have developed and preclinically evaluated two cyclic 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-minigastrin analogs radiolabeled with (111)In
Stephan Good et al.
European journal of nuclear medicine and molecular imaging, 35(10), 1868-1877 (2008-05-30)
Diethylenetriamine-pentaacetic acid (DTPA)-coupled minigastrins are unsuitable for therapeutic application with the available beta-emitting radiometals due to low complex stability. Low tumour-to-kidney ratio of the known radiopharmaceuticals is further limiting their potency. We used macrocyclic chelators for coupling to increase complex
Elisabeth Laabs et al.
Investigative radiology, 46(3), 196-201 (2010-12-09)
A variety of tumors in different organs with good accessibility to near-infrared light express the cholecystokinin-2 (CCK₂)/gastrin receptor. Therefore, the applicability of fluorescence optical imaging was assessed using a novel peptide probe. This study was approved by the regional animal
Anna Lucia Tornesello et al.
Journal of peptide science : an official publication of the European Peptide Society, 17(5), 405-412 (2011-02-26)
The development of suitable radioligands for targeting CCK-2 receptor expressing tumors, such as medullary thyroid carcinoma, is of great clinical interest. In the search for the best CCK-2R binding peptides, we have synthesized, evaluated and compared the CCK8 peptide (Asp-Tyr-Met-Gly-Trp-Met-Asp-PheNH(2)
Johanna Dalmo et al.
Oncology reports, 27(1), 174-181 (2011-10-14)
To be able to evaluate new radiopharmaceuticals and optimize diagnostic and therapeutic procedures, relevant animal models are required. The aim of this study was to evaluate the medullary thyroid carcinoma GOT2 animal model by analyzing the biodistribution of 177Lu-octreotate and
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