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Sigma-Aldrich

Adenosine 5′-triphosphate (ATP) disodium salt hydrate

vial of ~1 mg ATP

Synonym(s):

ATP disodium hydrate

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1 VIAL
$67.10
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$181.69
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$325.38

$67.10

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1 VIAL
$67.10
5 VIALS
$181.69
10 VIALS
$325.38

About This Item

Linear Formula:
C10H14N5O13P3Na2 · xH2O
CAS Number:
34369-07-8
Molecular Weight:
551.14 (anhydrous basis)
EC Number:
213-579-1
MDL number:
MFCD00150755
UNSPSC Code:
12352202
eCl@ss:
32160414
PubChem Substance ID:
24895005
NACRES:
NA.26

$67.10

Available to ship onApril 29, 2025Details

Request a Bulk Order

biological source

bacterial (Corynebacterium sp)

Quality Level

200

assay

≥90%

form

lyophilized powder

packaging

vial of ~1 mg ATP

storage temp.

−20°C

SMILES string

Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O

InChI

1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1

InChI key

NTBQNWBHIXNPRU-MSQVLRTGSA-L

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Application

Adenosine 5′-triphosphate (ATP) disodium salt hydrate has been:
  • used as a standard to measure ATP by bioluminescence method[1]
  • used in kinase buffer to assess the interaction between death-associated protein kinases (DAPK2) and 14-3-3-β[2]
  • used as a standard in ATP colorimetric assay[3]

Biochem/physiol Actions

Adenosine 5′-triphosphate (ATP) is one of the nucleoside triphosphate present in living system. It controls various biologic processes such as glucose metabolism, muscle contraction and neurotransmission. Apart from this, ATP serves as an important energy source for the cell. Administration of ATP might be useful in the treatment of non-small-cell lung cancer.[4]
Adenosine 5′-triphosphate was shown to have inhibitory effects on the inflammatory response by abrogating secretion of TNF-α and promoting secretion of Interleukin-10. [5]
P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems

Quantity

Each vial contains ~1.2 mg of Na2ATP • 3H2O equivalent to ~1.0 mg of ATP (2.0 μmol). Actual amount printed on the label.

Preparation Note

Prepared to be substantially vanadium-free.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLCQ5074
0000275383
0000393336
0000375689
0000381962

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Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia--ischemia
Chavez-Valdez R, et al.
Neuroscience, 219, 192-203 (2012)
Identification of novel death-associated protein kinase 2 interaction partners by proteomic screening coupled with bimolecular fluorescence complementation
Geering B, et al.
Molecular and Cellular Biology, 36(1), 132-143 (2016)
Jie Ge et al.
Journal of medicinal chemistry, 49(15), 4606-4615 (2006-07-21)
17-Allylamino-17-demethoxygeldanamycin (17-AAG)1 is a semisynthetic inhibitor of the 90 kDa heat shock protein (Hsp90) currently in clinical trials for the treatment of cancer. However, 17-AAG faces challenging formulation issues due to its poor solubility. Here we report the synthesis and
Randomized clinical trial of adenosine 5?-triphosphate in patients with advanced non-small-cell lung cancer
Agteresch HJ, et al.
Journal of the National Cancer Institute, 92(4), 321-328 (2000)
Els L R Swennen et al.
European journal of immunology, 35(3), 852-858 (2005-02-19)
In vitro studies suggest that extracellular nucleotides and nucleosides may be important regulators of inflammatory and immune responses. Most studies with adenosine 5'-triphosphate (ATP) have been performed in cell lines, which are remote from the human situation. The purpose of
View All Related Papers

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