Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

F9552

Sigma-Aldrich

Formoterol fumarate dihydrate

>98% (HPLC), solid, β₂-Adrenoreceptor agonist.

Synonym(s):

(R*,R*)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate, Formoterol hemifumarate salt monohydrate

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C19H24N2O4 · 0.5C4H4O4 · H2O
CAS Number:
183814-30-4
Molecular Weight:
420.46
MDL number:
MFCD11045919
UNSPSC Code:
12352200
PubChem Substance ID:
24278448
NACRES:
NA.77

product name

Formoterol fumarate dihydrate, >98% (HPLC)

Quality Level

100

assay

>98% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: soluble 20 mg/mL
H2O: insoluble

originator

Novartis

SMILES string

O.O.OC(=O)\C=C\C(O)=O.COc1ccc(C[C@H](C)NC[C@@H](O)c2ccc(O)c(NC=O)c2)cc1.COc3ccc(C[C@H](C)NC[C@@H](O)c4ccc(O)c(NC=O)c4)cc3

InChI

1S/2C19H24N2O4.C4H4O4.2H2O/c2*1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22;5-3(6)1-2-4(7)8;;/h2*3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22);1-2H,(H,5,6)(H,7,8);2*1H2/b;;2-1+;;/t2*13-,19+;;;/m00.../s1

InChI key

RATSWNOMCHFQGJ-TUYNVFRMSA-N

Gene Information

human ... ADRB2(154)

Looking for similar products? Visit Product Comparison Guide

Application

Formoterol fumarate dihydrate has been used:
  • as ß2-adrenergic agonist, to determine whether ß2-adrenergic receptor signaling was sufficient to induce up-regulation of select gene transcripts
  • as a ß2-adrenergic receptor agonist and a long term bronchodilator
  • as ß2-adrenergic receptor (ß2AR) agonist to recover renal function in ischemia-reperfusion injury (IRI) in mice

Biochem/physiol Actions

Formoterol fumarate dihydrate can be used along with budesonide to treat asthma.
β2-Adrenoreceptor agonist.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Repr. 2 - STOT RE 2 - STOT SE 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

beta-Adrenergic-stimulated macrophages: comprehensive localization in the M1-M2 spectrum
Lamkin D M, et al.
Brain, behavior, and immunity, 57(7), 338-346 (2016)
Targeting acetylcholine receptor M3 prevents the progression of airway hyperreactivity in a mouse model of childhood asthma
Patel K R, et al.
Faseb Journal, 31(10), 4335-4346 (2017)
Budesonide+ formoterol fumarate dihydrate for the treatment of asthma
Wolthers O D
Expert Opinion on Pharmacotherapy, 17(7), 1023-1030 (2016)
Robert B Cameron et al.
The Journal of pharmacology and experimental therapeutics, 369(1), 173-180 (2019-02-03)
Acute kidney injury (AKI) is the rapid loss of renal function after an insult, and renal proximal tubule cells (RPTCs) are central to the pathogenesis of AKI. The β2-adrenergic receptor (β2AR) agonist formoterol accelerates the recovery of renal function in
Proximal Tubule beta2 Adrenergic Receptor Mediates Formoterol-Induced Recovery of Mitochondrial and Renal Function After Ischemia-Reperfusion Injury.
Cameron R B, et al.
Journal of Pharmacology and Experimental Therapeutics, 31(10), 4335-4346 (2019)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service