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About This Item
Empirical Formula (Hill Notation):
C54H85N13O15S
CAS Number:
Molecular Weight:
1188.40
MDL number:
UNSPSC Code:
12352200
assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
CCC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)C(C)NC(=O)C(CC(O)=O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C2CCCN2C(=O)C3CCC(=O)N3)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(N)=O
Amino Acid Sequence
pGlu-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2
Biochem/physiol Actions
Tachykinin originally isolated from the salivary gland of octopus with structural homology to substance P; potent vasodilator and hypotensive agent; induces salivation and increases capillary permeability. Agonist at tachykinin NK-2/NK-3 receptors.
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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G Hölzemann et al.
International journal of peptide and protein research, 44(2), 105-111 (1994-08-01)
The synthesis of 11 cyclic hexapeptides, some of which contain a carbohydrate side chain moiety, is described in this paper. A glycosylamine was coupled without hydroxyl protecting groups either directly or via a butyric acid spacer to the side chain
U Gether et al.
The Journal of biological chemistry, 268(11), 7893-7898 (1993-04-15)
The NK1 (substance P) and NK3 (neurokinin B) receptors are G protein-coupled receptors sharing approximately 70% identity within the membrane-spanning domains. However, they each have a distinct pharmacological profile in respect of peptide binding. To identify epitopes that determine their
M Bergstrom et al.
Scandinavian journal of clinical and laboratory investigation, 55(8), 679-689 (1995-12-01)
Tachykinins are a family of peptides that may be present in and secreted from carcinoid tumours of mid-gut origin. They are likely to play a role in the pathogenesis of, e.g. the flush, dyspnoea and valvular heart disease seen in
P Björup et al.
Bioorganic & medicinal chemistry, 6(7), 891-901 (1998-09-08)
The influence of different reaction systems on alpha-chymotrypsin-catalyzed synthesis of eledoisin and LH-RH peptides from (7 + 4) and (5 + 5) fragments was investigated. The peptide yield was determined in the following systems: buffered aqueous media, frozen solutions, organic
R J Lukas et al.
Neurochemical research, 21(10), 1245-1257 (1996-10-01)
Nicotinic acetylcholine receptors (nAChR) are diverse members of the ligand-gated ion channel superfamily of neurotransmitter receptors and play critical roles in chemical signaling throughout the nervous system. Reports of effects of substance P (SP) on nAChR function prompted us to
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