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D7409

Sigma-Aldrich

2′,3′-Dideoxyguanosine 5′-triphosphate sodium salt

≥90% (HPLC)

Synonym(s):

ddGTP

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About This Item

Empirical Formula (Hill Notation):
C10H16N5O12P3
CAS Number:
68726-28-3
Molecular Weight:
491.18
MDL number:
MFCD00079152
UNSPSC Code:
41106305
PubChem Substance ID:
24894133
NACRES:
NA.51

Quality Level

100

assay

≥90% (HPLC)

form

powder

solubility

water: 5 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

[Na+].OP([O-])(=O)OP(O)(=O)OP(O)(=O)OC[C@@H]1CC[C@@H](O1)n2cnc3C(=O)NC(=N)Nc23

InChI

1S/C10H16N5O12P3.Na/c11-10-13-8-7(9(16)14-10)12-4-15(8)6-2-1-5(25-6)3-24-29(20,21)27-30(22,23)26-28(17,18)19;/h4-6H,1-3H2,(H,20,21)(H,22,23)(H2,17,18,19)(H3,11,13,14,16);/q;+1/p-1/t5-,6+;/m0./s1

InChI key

XCOBCPBPAINELA-RIHPBJNCSA-M

Gene Information

human ... HRAS(3265)

Application

2′,3′-Dideoxyguanosine 5′-triphosphate (ddGTP) is use as a chain terminator inhibitor and a inhibitor of telomerase(s).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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C Strahl et al.
Molecular and cellular biology, 16(1), 53-65 (1996-01-01)
The ribonucleoprotein telomerase, a specialized cellular reverse transcriptase, synthesizes one strand of the telomeric DNA of eukaryotes. We analyzed telomere maintenance in two immortalized human cell lines: the B-cell line JY616 and the T-cell line Jurkat E6-1, and determined whether
Y Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(17), 9491-9496 (1999-08-18)
The Taq DNA polymerase is the most commonly used enzyme in DNA sequencing. However, all versions of Taq polymerase are deficient in two respects: (i) these enzymes incorporate each of the four dideoxynucleoside 5' triphosphates (ddNTPs) at widely different rates
A Bart et al.
Nucleic acids research, 33(14), e124-e124 (2005-08-11)
The identification of methylated sites on bacterial genomic DNA would be a useful tool to study the major roles of DNA methylation in prokaryotes: distinction of self and nonself DNA, direction of post-replicative mismatch repair, control of DNA replication and
A Y Howe et al.
Hepatology (Baltimore, Md.), 23(1), 87-96 (1996-01-01)
Hepatitis B virus (HBV) replication is mediated by the viral polymerase that possesses three functional domains: primer, DNA polymerase/reverse transcriptase, and RNase H. Using the Pekin duck as an animal model, we demonstrate a novel mechanism of inhibition of duck
H Zhang et al.
Antiviral research, 24(1), 43-57 (1994-05-01)
Two mutants of HIV-1 reverse transcriptase (RT), Tyr-188-->His and Glu-138-->Arg have been prepared and their catalytic properties and sensitivities to inhibitors studied. As compared to wild type RT, a reduction in catalytic efficiency and turn over number was observed, especially
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