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Key Documents

D149

Sigma-Aldrich

Dihydro-β-erythroidine hydrobromide

solid

Synonym(s):

3β-1,6-Didehydro-14,17-dihydro-3-methoxy-16(15H)-oxaerythrinan-15-one hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C16H21NO3 · HBr
CAS Number:
Molecular Weight:
356.25
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

form

solid

optical activity

[α]22/D +99.2°, c = 0.90 in H2O(lit.)

color

white

solubility

ethanol: 5 mg/mL
H2O: 800 mg/mL

SMILES string

Br.CO[C@H]1CC=C2CC[N@@H]3CCC4=C(CC(=O)OC4)[C@]23C1

InChI

1S/C16H21NO3.BrH/c1-19-13-3-2-12-5-7-17-6-4-11-10-20-15(18)8-14(11)16(12,17)9-13;/h2,13H,3-10H2,1H3;1H/t13-,16-;/m0./s1

InChI key

GFIGWAJEIMHJJB-LINSIKMZSA-N

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Biochem/physiol Actions

Competitive nicotinic receptor antagonist.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Y T Wang et al.
Neuroscience, 40(3), 759-767 (1991-01-01)
The purpose of this study was to determine if ambigual oesophageal motoneurons of the rat possess functional nicotinic cholinoceptors. In urethane anaesthetized rats, acetylcholine (20-50 pmol) delivered micropneumophoretically from multibarrelled pipettes to the compact formation of the nucleus ambiguus produced
C Rapier et al.
Journal of neurochemistry, 54(3), 937-945 (1990-03-01)
Presynaptic nicotinic acetylcholine receptors on striatal nerve terminals modulate the release of dopamine. We have compared the effects of a number of nicotinic agonists and antagonists on a perfused synaptosome preparation preloaded with [3H]dopamine. (-)-Nicotine, acetylcholine, and the nicotinic agonists
Sean H White et al.
Journal of neurophysiology, 112(2), 446-462 (2014-04-18)
Nicotinic receptors form a diverse group of ligand-gated ionotropic receptors with roles in both synaptic transmission and the control of excitability. In the bag cell neurons of Aplysia, acetylcholine activates an ionotropic receptor, which passes inward current to produce a

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