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C9984

Sigma-Aldrich

Z-Gly-Leu-Phe-chloromethyl ketone

≥90% (TLC), solid

Synonym(s):

Z-GLF-CMK

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About This Item

Empirical Formula (Hill Notation):
C26H32N3O5Cl
CAS Number:
41658-44-0
Molecular Weight:
502.00
MDL number:
MFCD03452908
UNSPSC Code:
12352200
PubChem Substance ID:
329775298
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

200

assay

≥90% (TLC)

form

solid

solubility

DMSO: 1 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

CC(C)C[C@H](NC(=O)CNC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc2ccccc2)C(=O)CCl

InChI

1S/C26H32ClN3O5/c1-18(2)13-22(25(33)30-21(23(31)15-27)14-19-9-5-3-6-10-19)29-24(32)16-28-26(34)35-17-20-11-7-4-8-12-20/h3-12,18,21-22H,13-17H2,1-2H3,(H,28,34)(H,29,32)(H,30,33)/t21-,22-/m0/s1

InChI key

BRGPJZPHCVTNNI-VXKWHMMOSA-N

Amino Acid Sequence

Z-Gly-Leu-Phe-CMK

Biochem/physiol Actions

Cathepsin G inhibitor.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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Substrate binding site in bovine chymotrypsin A-gamma. A crystallographic study using peptide chloromethyl ketones as site-specific inhibitors.
D M Segal et al.
Biochemistry, 10(20), 3728-3738 (1971-09-28)

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