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C5423

Sigma-Aldrich

Clenbuterol hydrochloride

≥95% (TLC), powder, β2-adrenoceptor agonist

Synonym(s):

4-Amino-α-(t-butylaminomethyl)-3,5-dichlorobenzyl alcohol hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C12H18Cl2N2O · HCl
CAS Number:
21898-19-1
Molecular Weight:
313.65
EC Number:
244-643-7
MDL number:
MFCD00083280
UNSPSC Code:
12352200
PubChem Substance ID:
24892782
NACRES:
NA.77

product name

Clenbuterol hydrochloride, ≥95%

assay

≥95%

form

powder

drug control

Home Office Schedule 4.2

storage temp.

2-8°C

SMILES string

Cl.CC(C)(C)NCC(O)c1cc(Cl)c(N)c(Cl)c1

InChI

1S/C12H18Cl2N2O.ClH/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7;/h4-5,10,16-17H,6,15H2,1-3H3;1H

InChI key

OPXKTCUYRHXSBK-UHFFFAOYSA-N

Gene Information

human ... ADRB2(154)

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Application

Clenbuterol hydrochloride has been used:
  • as an agonist for β-adrenergic receptor (β-AR) from chick skeletal muscle
  • to induce hypertrophic effects in masseter, digastric, and temporalis muscles of rat
  • as a reference β-agonist standard in tandem mass spectrometry(MS-MS)

Biochem/physiol Actions

Clenbuterol hydrochloride is a β2-adrenoceptor agonist and bronchodilator. It is effective in improving peak expiratory flow rate (PEFR) in asthma patients. Clenbuterol is also a performance-enhancing drug as it stimulates the central nervous system and improves oxygen transport. Clenbuterol elicits cardio protective functionality in patients with dilated cardiomyopathy.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Carc. 2 - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A trial of clenbuterol in bronchial asthma.
Anderson G and Wilkins E
Thorax, 32(6), 717-719 (1977)
C A Izeboud et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 48(9), 497-502 (1999-10-16)
To investigate the suppressive effects of the beta-agonist clenbuterol on the release of TNF-alpha and IL-6 in a lipopolysaccharide (LPS)-model of inflammation, both in vitro and in vivo. Human U-937 cell line (monocyte-derived macrophages), and male Wistar rats (200-250 g).
Vipin Arora et al.
Molecular pain, 17, 1744806921997206-1744806921997206 (2021-04-09)
Beta 2 adrenergic receptor (β2 AR) activation in the central and peripheral nervous system has been implicated in nociceptive processing in acute and chronic pain settings with anti-inflammatory and anti-allodynic effects of β2-AR mimetics reported in several pain states. In
beta2-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats
Zhang Q, et al.
British Journal of Pharmacology, 160(6), 1561-1572 (2010)
Clinton E Canal et al.
Learning & memory (Cold Spring Harbor, N.Y.), 15(9), 677-686 (2008-09-06)
Infusions of CREB antisense into the amygdala prior to training impair memory for aversive tasks, suggesting that the antisense may interfere with CRE-mediated gene transcription and protein synthesis important for the formation of new memories within the amygdala. However, the
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