C4285
Acetyl-Calpastatin (184-210) human
~95% (HPLC), powder
Synonym(s):
Acetyl-Calpain inhibitor fragment 184-210, CS peptide
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About This Item
Empirical Formula (Hill Notation):
C142H230N36O44S
CAS Number:
Molecular Weight:
3177.63
MDL number:
UNSPSC Code:
12352200
Amino Acid Sequence
Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2
Biochem/physiol Actions
Inhibitor of calpain which induces an increase in secreted amyloid β-protein 1-42.
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Wilasinee Suwanjang et al.
Neuroscience letters, 526(1), 49-53 (2012-08-18)
Methamphetamine (METH) is an abused psychostimulant drug that can cause neurotoxicity to dopaminergic cells. It has been demonstrated that METH can induce caspase- and calpain-dependent death cascades. The purpose of the present study was to investigate the functional role of
Robert L Campbell et al.
The Biochemical journal, 447(3), 335-351 (2012-10-06)
Calpains are a family of complex multi-domain intracellular enzymes that share a calcium-dependent cysteine protease core. These are not degradative enzymes, but instead carry out limited cleavage of target proteins in response to calcium signalling. Selective cutting of cytoskeletal proteins
Yoko Sakamoto et al.
Clinical calcium, 23(4), 519-525 (2013-04-03)
Calpains are Ca(2 +) -dependent cysteine proteases. Fifteen gene products of calpains are expressed in mammals. Among them, Calpain 1 and Calpain 2 are ubiquitously expressed and have been investigated extensively. Under the physiological conditions, calpain activity is strictly regulated
E Rodero et al.
Animal biotechnology, 24(1), 15-24 (2013-02-12)
The aim was to analyze the allelic and genotypic frequencies for two genes associated with tenderness of meat (CAPN1 and CAST) and one with fat deposits (DGAT1) in three endangered Spanish cattle breeds: Berrenda en Colorado (BC), Berrenda en Negro
Quentin Raimbourg et al.
PloS one, 8(4), e60469-e60469 (2013-04-09)
Conventional calpains are ubiquitous cysteine proteases whose activity is promoted by calcium signaling and specifically limited by calpastatin. Calpain expression has been shown to be increased in human malignant cells, but the contribution of the calpain/calpastatin system in tumorigenesis remains
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