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C3705

Sigma-Aldrich

C Reactive Protein Fragment 174-185

≥97% (HPLC)

Synonym(s):

Ile-Tyr-Leu-Gly-Gly-Pro-Phe-Ser-Pro-Asn-Val-Leu

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About This Item

Empirical Formula (Hill Notation):
C62H93N13O16
CAS Number:
160369-86-8
Molecular Weight:
1276.48
MDL number:
MFCD00236934
UNSPSC Code:
12352200
PubChem Substance ID:
329775042

assay

≥97% (HPLC)

form

solid

UniProt accession no.

P02741

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O

InChI

1S/C62H93N13O16/c1-9-36(8)51(64)59(87)70-42(28-38-19-21-39(77)22-20-38)54(82)67-40(25-33(2)3)53(81)66-30-49(79)65-31-50(80)74-23-13-17-46(74)57(85)68-41(27-37-15-11-10-12-16-37)55(83)72-45(32-76)61(89)75-24-14-18-47(75)58(86)69-43(29-48(63)78)56(84)73-52(35(6)7)60(88)71-44(62(90)91)26-34(4)5/h10-12,15-16,19-22,33-36,40-47,51-52,76-77H,9,13-14,17-18,23-32,64H2,1-8H3,(H2,63,78)(H,65,79)(H,66,81)(H,67,82)(H,68,85)(H,69,86)(H,70,87)(H,71,88)(H,72,83)(H,73,84)(H,90,91)/t36-,40-,41-,42-,43-,44-,45-,46-,47-,51-,52-/m0/s1

InChI key

KODGVWMUDZVVII-FVTMRLMCSA-N

Gene Information

human ... CRP(1401)

Amino Acid Sequence

Ile-Tyr-Leu-Gly-Gly-Pro-Phe-Ser-Pro-Asn-Val-Leu

Biochem/physiol Actions

C Reactive Protein (CRP) Fragment 174-185, CRP174-185, is a synthetic peptide fragment of CRP that induces the circulation of soluble IL-6 receptor (sIL-6R) and modulates chemotaxis. CRP174-185 and other CRP peptides such as 77-82 and 201-206 are use to resolve the function of amino acid sequences and domains withing CRP.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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M J Thomassen et al.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy, 13(1), 1-6 (1993-01-01)
We have previously shown that native human C-reactive protein (CRP) produces antitumor effects in experimental animals, and that these effects are mediated primarily through macrophages. More recently, we have observed that RS-83277, a synthetic peptide derived from CRP, appears to
S A Jones et al.
The Journal of experimental medicine, 189(3), 599-604 (1999-02-02)
The soluble interleukin 6 receptor (sIL-6R) circulates at elevated levels in various diseases. This suggests that inflammatory mediators control sIL-6R release. Through examination of human neutrophils, it was found that the acute phase reactant C-reactive protein (CRP) activates a threefold
Effect of human C-reactive protein on chemokine and chemotactic factor-induced neutrophil chemotaxis and signaling.
Zhong W, Zen Q, Tebo J, et al.
Journal of Immunology, 161, 2433-2540 (1998)
Stefan Rose-John et al.
Expert opinion on therapeutic targets, 11(5), 613-624 (2007-05-01)
IL-6 plays a pivotal role in immune responses and certain oncologic conditions. The intense investigation of its biological activity and function led to the discovery of two different IL-6-driven signalling pathways. Binding to the membrane-bound IL-6 receptor (mIL-6R, CD126) causes
Tarek Khreiss et al.
The Journal of biological chemistry, 277(43), 40775-40781 (2002-08-29)
Human neutrophil granulocytes die rapidly, and their survival is contingent upon rescue from programmed cell death by signals from the environment. Here we report that a novel signal for delaying neutrophil apoptosis is the classic acute phase reactant, C-reactive protein

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