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B7283

Sigma-Aldrich

Benserazide hydrochloride

≥98% (HPLC), solid, L-aromatic amino acid decarboxylase inhibitor

Synonym(s):

DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride

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1 G
$123.00
5 G
$429.00

About This Item

Empirical Formula (Hill Notation):
C10H15N3O5 · HCl
CAS Number:
14919-77-8
Molecular Weight:
293.70
EC Number:
238-991-9
MDL number:
MFCD00078571
UNSPSC Code:
12352125
PubChem Substance ID:
24277886
NACRES:
NA.77

$123.00

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Product Name

Benserazide hydrochloride, ≥98% (HPLC), solid

biological source

synthetic

Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

H2O: 10 mg/mL

originator

Roche

storage temp.

room temp

SMILES string

Cl.NC(CO)C(=O)NNCc1ccc(O)c(O)c1O

InChI

1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H

InChI key

ULFCBIUXQQYDEI-UHFFFAOYSA-N

Gene Information

human ... DDC(1644)

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General description

Benserazide is a peripheral decarboxylase inhibitor.[1]

Application

Benserazide has been used:
  • to inhibit dopa-decarboxylase[2]
  • to induce dyskinesia[3]
  • to test on purified bacterial TDCs to assess the extent to which it could affect bacterial decarboxylases[4]
  • as a peripheral dopa decarboxylase inhibitor to treat mice[5]

Biochem/physiol Actions

Benserazide can block HK2 enzymatic activity in vitro. It is used along with levodopa to treat Parkinson′s disease. [6]
Inhibitor of L-aromatic amino acid decarboxylase.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH7703
BCCF3274
BCCC7474
BCBZ1809
BCBT2136

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Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2
Li W, et al.
Journal of Experimental & Clinical Cancer Research, 36(1), 58-58 (2017)
24 - Extrapyramidal movement disorders and spasticity
Waller DG, et al.
Medical Microbiology, 325-336 (2018)
Developmental and evolutionary basis for drought tolerance of the Anopheles gambiae embryo
Goltsev Y, et al.
Developmental Biology, 330(2), 462-470 (2009)
Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson?s disease
van KSP, et al.
Nature Communications, 10(1), 310-310 (2019)
Detection of behavioral impairments correlated to neurochemical deficits in mice treated with moderate doses of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine
Tillerson JL, et al.
Experimental Neurology, 178, 80-90 (2002)
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Questions

  1. What is the recommended storage temperature for Benserazide hydrochloride (Product B7283) after the drug is suspended in water?

    1 answer

    1. Benserazide hydrochloride is soluble in water and should be dissolved in oxygen-free boiled water containing 0.1% sodium metabisulfite or other antioxidants. The solutions decompose on exposure to light and air. Benserazide HCl is a tan, photosensitive solid and should be stored tightly sealed at -4°C, protected from exposure to light. It is not recommended to store the aqueous solution for more than one day.

      Additionally, the product is subject to oxidation, and it is advisable to make solutions fresh daily. The product should be stored, as supplied, at room temperature for up to 1 year, and it should be protected from light.

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