All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C60H87N19O13
CAS Number:
Molecular Weight:
1282.45
MDL number:
UNSPSC Code:
12352200
Recommended Products
assay
≥95% (HPLC)
storage temp.
−20°C
SMILES string
N[C@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc4ccccc4)C(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Amino Acid Sequence
D-Arg-Arg-Pro-Hydroxy-Pro-Gly-Phe-Ser-D-Phe-Phe-Arg
Biochem/physiol Actions
Bradykinin antagonist.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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S Pyne et al.
British journal of pharmacology, 110(1), 477-481 (1993-09-01)
1. Guinea-pig tracheal smooth muscle cells were isolated and maintained in culture for 14-21 days prior to the study of the effect of a selective bradykinin B1 agonist and B2 antagonists upon bradykinin-stimulated phospholipase C and D activities. 2. Bradykinin-stimulated
W Miska et al.
Archives of andrology, 33(1), 1-5 (1994-07-01)
Washed human spermatozoa were coincubated at a constant concentration of bradykinin (BK) (10(-8) M) with different concentrations of the bradykinin antagonists Hoe 140, (Thi5,8, D-Phe7)-BK, and D-Arg(Hyp3, D-Phe7)-BK. In the range between 10(-10) and 10(-5) M none of the tested
D Scherrer et al.
Fundamental & clinical pharmacology, 12(2), 188-193 (1998-05-05)
This study investigated the effect of the non-peptidic B2 bradykinin (BK) receptor antagonist WIN 64338 on BK binding and BK-induced inositol phosphate formation on guinea-pig tracheal smooth muscle cells in culture. The presence of specific and saturable binding sites for
R Forteza et al.
American journal of respiratory and critical care medicine, 154(1), 36-42 (1996-07-01)
We reported previously that the development of airway hyperresponsiveness (AHR) 24 h after antigen challenge in allergic sheep was associated with increased tissue kallikrein activity (TK) and decreased alpha-1-proteinase inhibitor (alpha 1-PI) activity in bronchoalveolar fluid (BAL). The inverse correlation
D H Wolsing et al.
The Journal of pharmacology and experimental therapeutics, 266(1), 253-261 (1993-07-01)
We have previously shown that the mechanism for the rapid desensitization in bradykinin (BDK)-stimulated inositol monophosphate (IP) production in NG108-15 cells involves both a rapid loss of receptors from the cell surface and an uncoupling of the receptor:G-protein:phospholipase C (PLC)
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