A9052
Atrial Natriuretic Peptide chicken
≥95% (HPLC)
Synonym(s):
ANF 1-29
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About This Item
Empirical Formula (Hill Notation):
C124H211N47O40S5
CAS Number:
Molecular Weight:
3160.62
MDL number:
UNSPSC Code:
12352200
assay
≥95% (HPLC)
UniProt accession no.
storage temp.
−20°C
Gene Information
chicken ... LOC395765(395765)
Amino Acid Sequence
Met-Met-Arg-Asp-Ser-Gly-Cys-Phe-Gly-Arg-Arg-Ile-Asp-Arg-Ile-Gly-Ser-Leu-Ser-Gly-Met-Gly-Cys-Asn-Gly-Ser-Arg-Lys-Asn [Disulfide bridge: 7–23]
Biochem/physiol Actions
Atrial natriuretic peptide (ANP) is synthesized in myoendocrine cells of the heart from which it is released into the circulation. It exerts natriuretic, diuretic, and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure homeostasis.
Quality
Has diuretic-natriuretic and hypotensive activity similar to mammalian ANF.
Preparation Note
Originally isolated from atrium.
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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A Miyata et al.
Biochemical and biophysical research communications, 155(3), 1330-1337 (1988-09-30)
Morphological and pharmacological observations have suggested that chicken atrial natriuretic peptide (ANP) is different from mammalian ANP. The present survey for the as yet unidentified ANP in chicken heart was performed by monitoring the relaxant effect on chick rectum. From
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