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A8802

Sigma-Aldrich

Antide

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C82H108ClN17O14
CAS Number:
112568-12-4
Molecular Weight:
1591.29
MDL number:
MFCD00133104
UNSPSC Code:
12352200
PubChem Substance ID:
24891367
NACRES:
NA.32

assay

≥97% (HPLC)

form

powder

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)C(CCCCNC(=O)c1cccnc1)NC(=O)C(CCCCNC(=O)c2cccnc2)NC(=O)C(CO)NC(=O)C(Cc3cccnc3)NC(=O)C(Cc4ccc(Cl)cc4)NC(=O)C(Cc5ccc6ccccc6c5)NC(C)=O)C(=O)NC(CCCCNC(C)C)C(=O)N7CCCC7C(=O)NC(C)C(N)=O

InChI

1S/C82H108ClN17O14/c1-50(2)41-65(76(108)95-64(26-11-12-37-88-51(3)4)82(114)100-40-18-27-70(100)81(113)91-52(5)71(84)103)96-75(107)63(25-10-14-39-90-73(105)60-23-17-36-87-48-60)93-74(106)62(24-9-13-38-89-72(104)59-22-16-35-86-47-59)94-80(112)69(49-101)99-79(111)68(45-56-19-15-34-85-46-56)98-78(110)67(43-54-29-32-61(83)33-30-54)97-77(109)66(92-53(6)102)44-55-28-31-57-20-7-8-21-58(57)42-55/h7-8,15-17,19-23,28-36,42,46-48,50-52,62-70,88,101H,9-14,18,24-27,37-41,43-45,49H2,1-6H3,(H2,84,103)(H,89,104)(H,90,105)(H,91,113)(H,92,102)(H,93,106)(H,94,112)(H,95,108)(H,96,107)(H,97,109)(H,98,110)(H,99,111)

InChI key

QRYFGTULTGLGHU-UHFFFAOYSA-N

Gene Information

rat ... Gnrhr(81668)

Amino Acid Sequence

Ac-Ala-Phe-Ala-Ser-Lys-Lys-Leu-Lys-Pro-Ala-NH2

Application

Antide has been used as a gonadotropin-releasing hormone (GnRH) antagonist to study its effects on regulating apoptosis in a bovine granulosa cell line (BGC-1)[1] and to determine its GnRH effects on cleavage rates of bovine oocytes in vitro.[2]

Biochem/physiol Actions

Antide is a luteinizing hormone-releasing hormone (LHRH) antagonist with high anti-ovulatory and negligible histamine release activity.[3]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360

Hazard Classifications

Repr. 1B

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCCC2014
BCBJ6857V
BCBJ6857
BCBG9289V
BCBG9289

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M Zerani et al.
Domestic animal endocrinology, 40(1), 51-59 (2010-10-22)
The main objective of this study was to examine the modulatory in vitro effects of gonadotropin-releasing hormone (GnRH) on isolated Leydig cells of adult alpaca (Lama pacos) testis. We first evaluated the presence of GnRH receptor (GnRHR) and cyclooxygenase (COX)
Shira G Ziegler et al.
Hormones and behavior, 58(5), 705-713 (2010-08-10)
Though several studies have suggested that estradiol improves hippocampal-dependent spatial memory, the effects of other hormones in the hypothalamic-pituitary-gonadal axis on memory have largely been ignored. Estradiol and luteinizing hormone (LH) are generally inversely related and LH may significantly affect
S K Kang et al.
Endocrinology, 141(1), 72-80 (1999-12-30)
Epithelial ovarian cancer, which accounts for 80-90% of all ovarian cancers, is the most common cause of death from gynecological malignancies and is believed to originate from the ovarian surface epithelium. In the present study we investigated the expression of
Gonadotropin-releasing hormone increases cleavage rates of bovine oocytes fertilized in vitro.
Funston, et al.
Biology of Reproduction, 53, 541-545 (2019)
De-Laine M Cyrenne et al.
Hormones and behavior, 60(5), 625-631 (2011-09-17)
Human adolescents exhibit higher levels of novelty-seeking behaviour than younger or older individuals, and novelty-seeking is higher in males than females from adolescence onwards. Gonadal hormones, such as testosterone and estradiol, have been suggested to underlie age and sex difference
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