assay
≥85%
solubility
H2O: soluble
shipped in
wet ice
storage temp.
2-8°C
Application
β-Amanitin inhibits RNA polymerase II and III in eukaryotic cells. β-Amanitin binds to the bridging helix of RNA polymerase II inhibiting the translocation of RNA and DNA required for transcription. β-Amanitin slows the rate of transcription roughly 1000 fold.
Biochem/physiol Actions
Inhibits eukaryotic RNA polymerase II and III; does not inhibit RNA polymerase I or bacterial RNA polymerase; inhibits mammalian protein synthesis.
Toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but not RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis.
Caution
Highly toxic
Preparation Note
Supplied as 0.1 mg β-Amanitin bound to 0.5 mg poly-L-lysine HCL (25,000 ave. mol. wt) in 3.4 mg of NaCl
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk_germany
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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