A6938
Pituitary adenylate cyclase activating polypeptide amide fragment 6-27
Synonym(s):
PACAP-6-27
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About This Item
Empirical Formula (Hill Notation):
C121H193N33O31S
CAS Number:
Molecular Weight:
2638.09
MDL number:
UNSPSC Code:
41106305
composition
Peptide content, ~65%
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... ADCYAP1(116)
Amino Acid Sequence
Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH2
Biochem/physiol Actions
Inhibitor of PACAP-27.
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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P Robberecht et al.
Molecular pharmacology, 42(2), 347-355 (1992-08-01)
In AR 4-2J rat pancreatic acinar cell membranes, receptors for the two pituitary adenylate cyclase-activating peptides (PACAP) PACAP-27 (the short version of PACAP) and PACAP-38 [the long version, with a carboxyl-terminal (residues 28-38) extension] can be subdivided into (a) type
R Gaspo et al.
The American journal of physiology, 272(5 Pt 2), R1606-R1612 (1997-05-01)
The goal of the present study was to characterize the adrenal catecholamine response to exogenous vasoactive intestinal peptide (VIP) in anesthetized dogs. We studied the potential involvement of mechanism(s) mediated by muscarinic receptors, L-type Ca2+ channels, VIP-ergic receptors, or pituitary
K Filipsson et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 279(2), R424-R432 (2000-08-12)
Pituitary adenylate cyclase-activating polypeptide (PACAP) is localized to pancreatic ganglia governing the parasympathetic nerves, which contribute to prandial insulin secretion. We hypothesized that this contribution involves PACAP and show here that the PACAP receptor antagonist PACAP-(6---27) (1.5 nmol/kg iv) reduces
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