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A6916

Sigma-Aldrich

Atrial Natriuretic Peptide fragment 4-28 human

≥97% (HPLC)

Synonym(s):

Auriculin® B, hANF 4-28

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About This Item

Empirical Formula (Hill Notation):
C112H175N39O35S3
CAS Number:
95896-08-5
Molecular Weight:
2724.02
MDL number:
MFCD00076232
UNSPSC Code:
12352200

assay

≥97% (HPLC)

UniProt accession no.

P01160

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc4ccc(O)cc4)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCNC(N)=N

Gene Information

human ... NPPA(4878)

application

Useful as an immunogen for producing antibodies to hANF.

Biochem/physiol Actions

Atrial natriuretic peptide (ANP) is synthesized in myoendocrine cells of the heart from which it is released into the circulation. It exerts natriuretic, diuretic, and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure homeostasis.

Legal Information

Auriculin is a registered trademark of California Biotechnology, Inc.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
012H03721
012H03722
012H03723

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L S Weisberg et al.
Archives of internal medicine, 157(16), 1833-1838 (1997-09-18)
Acute tubular necrosis (ATN) is the most common type of acute renal failure in hospitalized patients and is associated with a high morbidity and mortality. The cause of ATN can be divided into nephrotoxic, ischemic, or mixed. To test the
K C Lee et al.
American journal of hypertension, 3(4), 262-267 (1990-04-01)
The renal and hemodynamic responses to intravenous anaritide, a human atrial natriuretic factor [102-126] at 0.3 to 20 micrograms/kg in conscious rhesus monkeys with and without acute extracellular hypervolemia were analyzed and compared. Acute isotonic saline loading (intravenous bolus at
Acute renal failure--the promise of new therapies.
H D Humes
The New England journal of medicine, 336(12), 870-871 (1997-03-20)
A B Weder et al.
Hypertension (Dallas, Tex. : 1979), 10(6), 582-589 (1987-12-01)
Synthetic atrial natriuretic factor (ANF) was administered in ascending doses (0.03, 0.20, 0.45 microgram/kg/min) to eight mildly essential hypertensive men on high (200 mEq/day) or low (10 mEq/day) sodium diets. Responses of blood pressure, heart rate, urinary volume and electrolyte
T A Fried et al.
The American journal of physiology, 255(2 Pt 2), F313-F316 (1988-08-01)
With micropuncture techniques, the present study examined the delivery of chloride to the superficial late distal tubule and the base and tip of the papillary collecting duct in rats treated with either Wy 47663, a synthetic analogue of atrial natriuretic
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