A4316
Anantin from Streptomyces coerulescens
≥90% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C90H111N21O24
CAS Number:
Molecular Weight:
1870.97
MDL number:
UNSPSC Code:
12352200
assay
≥90% (HPLC)
storage temp.
−20°C
Amino Acid Sequence
Cyclo(Gly-Phe-Ile-Gly-Trp-Gly-Asn-β-Asp)-Ile-Phe-Gly-His-Tyr-Ser-Gly-Asp-Phe
Biochem/physiol Actions
Competitive antagonist at atrial natriuretic peptide NPR-A receptors.
Other Notes
A cyclic peptide
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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D F Wyss et al.
The Journal of antibiotics, 44(2), 172-180 (1991-02-01)
Anantin, a naturally occurring peptide from Streptomyces coerulescens, binds competitively to the receptor of atrial natriuretic factor (ANF) from bovine adrenal cortex (Kd = 0.6 microM) and acts as ANF antagonist. Protein chemical data and FAB-MS have identified anantin to
Sandra L Hrometz et al.
Toxicology letters, 206(2), 234-237 (2011-08-11)
MDMA (3,4-methylenedioxymethamphetamine) induces thermogenesis in a mitochondrial uncoupling protein 3-dependent manner. There is evidence that this hyperthermia is mediated in part by the lipolytic release of free fatty acids, that subsequently activate uncoupling protein 3 in skeletal muscle mitochondria. We
S Nachshon et al.
The American journal of physiology, 268(3 Pt 1), E428-E432 (1995-03-01)
Atrial natriuretic peptide (ANP) is a hormone-secreted predominantly by atrial myocytes. ANP exerts many of its actions via activation of the particulate guanylyl cyclase receptor ANPR-A and the formation of guanosine 3',5'-cyclic monophosphate (cGMP), which serves as a second messenger
Cell-specific manipulation of second messengers; a toolbox for integrative physiology in Drosophila.
Martin Kerr et al.
Current biology : CB, 14(16), 1468-1474 (2004-08-25)
Every living cell must detect, and respond appropriately to, external signals. The functions of intracellular second messengers, such as guanosine 3'5'-cyclic monophosphate (cGMP), adenosine 3'5'-cyclic monophosphate (cAMP), and intracellular calcium, are thus intensively studied. However, artifact-free manipulation of these messengers
W Weber et al.
The Journal of antibiotics, 44(2), 164-171 (1991-02-01)
Anantin, a peptide binding to the receptor of the atrial natriuretic factor (ANF) was isolated from a strain of Streptomyces coerulescens. The molecule consists of 17 natural L-amino acids which form a peptidic ring system. It has a MW of
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