A1546
N-(4-Aminobutyl)-5-chloro-1-naphthalenesulfonamide hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C14H17ClN2O2S · HCl
CAS Number:
Molecular Weight:
349.28
MDL number:
UNSPSC Code:
41116107
storage temp.
2-8°C
SMILES string
Cl.NCCCCNS(=O)(=O)c1cccc2c(Cl)cccc12
Biochem/physiol Actions
Antitumor agent which inhibits blood platelet aggregation; a calmodulin antagonist
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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H Hidaka et al.
Proceedings of the National Academy of Sciences of the United States of America, 78(7), 4354-4357 (1981-07-01)
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and its derivatives are putative calmodulin antagonists that bind to calmodulin and inhibit Ca2+/calmodulin-regulated enzyme activities. Autoradiographic studies using tritiated W-7 showed that this compound penetrates the cell membrane, is distributed mainly in the cytoplasm, and inhibits proliferation
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