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About This Item
Empirical Formula (Hill Notation):
C21H25ClN2O3 · 2HCl
CAS Number:
Molecular Weight:
461.81
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.25
Pricing and availability is not currently available.
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Quality Level
assay
≥98.0% (HPLC)
form
powder
SMILES string
Cl[H].Cl[H].OC(=O)COCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3
InChI
1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H
InChI key
PGLIUCLTXOYQMV-UHFFFAOYSA-N
Gene Information
human ... HRH1(3269)
Application
Cetirizin (CTZ) may be used in studies on the treatment of cutaneous mastocytosis (urticaria pigmentosa). Cetirizin, an antihistamine, may be useD in allergy research as an antagonist of the histamine 1 receptor (H1R).
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M Gschwandtner et al.
Allergy, 68(1), 37-47 (2012-11-20)
Defects in keratinocyte differentiation and skin barrier are important features of inflammatory skin diseases like atopic dermatitis. Mast cells and their main mediator histamine are abundant in inflamed skin and thus may contribute to disease pathogenesis. Human primary keratinocytes were
K Rossbach et al.
Neuroscience, 190, 89-102 (2011-06-22)
Histamine has long been recognised as a classical inducer of pruritus. However, the specific mechanism of histamine-induced itch has still not been fully understood. The H1 and H4 receptor appear to be key components in the induction of itch. The
Arnold Bahlmann et al.
Chemosphere, 89(11), 1278-1286 (2012-06-12)
Carbamazepine (CBZ), caffeine and cetirizine were monitored by enzyme-linked immunosorbent assays (ELISAs) in surface and wastewaters from Berlin, Germany. This fast and cost-efficient method enabled to assess the spatial and temporal variation of these anthropogenic markers in a high-throughput screening.
Céline Caillet et al.
British journal of clinical pharmacology, 74(5), 886-889 (2012-03-13)
The physicochemical properties of racemates and stereoisomers of medicines can differ significantly, and this may affect the side-effect profile in addition to the pharmacokinetics and intended pharmacology. This is a study to investigate the profile of adverse drug reactions of
Joya S Griffin et al.
The Canadian veterinary journal = La revue veterinaire canadienne, 53(1), 47-50 (2012-07-04)
Cetirizine hydrochloride was administered orally at 5 mg/cat, q24h, to 32 cats with allergic skin disease. Pruritus was reduced in 41% (13/32) of the cats. The antipruritic effect was repeatable and sustainable. There was no significant association between patient age
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