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A8251

Sigma-Aldrich

Acriflavine hydrochloride

Powder

Synonym(s):

3,6-Diamino-10-methylacridinium chloride hydrochloride, Euflavine

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About This Item

CAS Number:
8063-24-9
Beilstein/REAXYS Number:
6265525
MDL number:
MFCD00069039
UNSPSC Code:
12171500
PubChem Substance ID:
24891216
NACRES:
NA.47

product name

Acriflavine hydrochloride, fluorescent dye

Quality Level

200

form

powder

composition

Acriflavine HCL content, 10-50%
Proflavine HCL, 25-70%

color

faint brown to brown, and Orange to Dark Orange and Red to Very Dark Red

mp

260 °C (dec.) (lit.)

solubility

H2O: 1 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Cl-].Cl[H].Cl[H].Nc1ccc2cc3ccc(N)cc3nc2c1.C[n+]4c5cc(N)ccc5cc6ccc(N)cc46

InChI

1S/C14H13N3.C13H11N3.3ClH/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;;;/h2-8H,1H3,(H3,15,16);1-7H,14-15H2;3*1H

InChI key

MKLTXAHQKDVBLY-UHFFFAOYSA-N

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Application

In living mice, acriflavine hydrochloride has been used in the confocal laser endomicroscopy to check the crypt structure in mucosa. It has also been used in Neurospora strain selection by checking the acriflavine resistance.

Biochem/physiol Actions

Acriflavine hydrochloride is a fluorescent dye. It is used as a topical contrast agent. It mainly stains nuclei and is applied to tissues before microscopy.

Other Notes

A mixture of 3,6-diamino-10-methylacridinium (acriflavin) and 3,6-diaminoacridine (proflavin)

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SHBR5332
SHBR8114
SHBR3518
SHBM0542
SHBQ3710

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Emerson JM, et al.
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