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541850

Sigma-Aldrich

2-Amino-4-chlorobenzenethiol

96%

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About This Item

Linear Formula:
H2NC6H3(Cl)SH
CAS Number:
Molecular Weight:
159.64
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

assay

96%

mp

56-61 °C (lit.)

functional group

chloro

SMILES string

Nc1cc(Cl)ccc1S

InChI

1S/C6H6ClNS/c7-4-1-2-6(9)5(8)3-4/h1-3,9H,8H2

InChI key

NGIRMPARLVGMPX-UHFFFAOYSA-N

General description

2-Amino-4-chlorobenzenethiol reacts with aromatic aldehydes and cyclohexanecarboxaldehyde to afford the corresponding thiazole and thiazoline derivatives. It undergoes oxidation in the presence of 1-n-butyl-3-methylimidazolium methylselenite, [bmim][SeO2(OCH3)] to form the corresponding symmetrical disulfide.

Application

2-Amino-4-chlorobenzenethiol may be used in the synthesis of:
  • 2,3-dihydro-1,5-benzothiazepin-4-(5H)-ones
  • 8-chloro-1-azaphenothiazine
  • 5-chloro-2-(4-methoxyphenyl)-2,3-dihydro-1,3,2-benzothiazaphosphole 2-sulfide

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Base-free oxidation of thiols to disulfides using selenium ionic liquid.
Thurow S, et al.
Tetrahedron Letters, 52(5), 640-643 (2011)
Efficient synthesis of heterophosphole-2-sulfides by solvent-free microwave reaction.
Seijas JA, et al.
Tetrahedron, 66(41), 8210-8213 (2010)
Brajendra S Kusmariya et al.
Journal of molecular modeling, 21(11), 278-278 (2015-10-07)
Three mononuclear coordination complexes of Co(II), Ni(II), and Cu(II) have been synthesized from 2,4-dichloro-6-{(E)-[(5-chloro-2-sulfanylphenyl)imino]methyl}phenol ligand (H 2 L) obtained by simple condensation reaction of 3,5-dichloro-2-hydroxybenzaldehyde and 2-amino-4-chlorobenzenethiol and characterized by elemental analysis, spectral (FT-IR, electronic, and (1)H-NMR), molar conductance, thermal
SUBSTITUTED 2,3-DIHYDRO-1,5-BENZOTHIAZEPIN-4(5H)-ONES AND 3,4-DIHYDRO-2-PHENYL-(2H)-1,6-BENZOTHIAZOCIN-5(6H)-ONES.
J KRAPCHO et al.
Journal of medicinal chemistry, 6, 544-546 (1963-09-01)
10-(Dialkylaminoalkyl)-pyrido [3, 2-b][1, 4] benzothiazine (1-azaphenothiazine) and related compounds.
Yale HL and Sowinski F.
Journal of the American Chemical Society, 80(7), 1651-1654 (1958)

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