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About This Item
Empirical Formula (Hill Notation):
C10H8O3
CAS Number:
Molecular Weight:
176.17
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
assay
98%
mp
194-197 °C (lit.)
SMILES string
Cc1c(oc2ccccc12)C(O)=O
InChI
1S/C10H8O3/c1-6-7-4-2-3-5-8(7)13-9(6)10(11)12/h2-5H,1H3,(H,11,12)
InChI key
YMZTUCZCQMQFMK-UHFFFAOYSA-N
General description
3-Methylbenzofuran-2-carboxylic acid is a benzofuran derivative. It undergoes palladium-catalyzed cross-coupling reaction with 4-iodoanisole and diphenyliodonium triflate under different reaction conditions to form the corresponding biaryl.
Application
3-Methylbenzofuran-2-carboxylic acid may be used in the preparation of 3-methyl-N-phenylbenzofuran-2-carboxamide by reacting with aniline.
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Karla-Sue C Marriott et al.
Bioorganic & medicinal chemistry, 20(23), 6856-6861 (2012-10-23)
Novel benzofuran-2-carboxamide ligands, which are selective for sigma receptors, have been synthesized via a microwave-assisted Perkin rearrangement reaction and a modified Finkelstein halogen-exchange used to facilitate N-alkylation. The ligands synthesized are the 3-methyl-N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamides (KSCM-1, KSCM-5 and KSCM-11). The benzofuran-2-carboxamide structure
Synthesis of biaryls via decarboxylative Pd-catalyzed cross-coupling reaction.
Becht JM, et al.
Organic Letters, 9(9), 1781-1783 (2007)
Biaryl Synthesis via Decarboxylative Pd-Catalyzed Reactions of Arenecarboxylic Acids and Diaryliodonium Triflates.
Becht JM and Drian CL.
Organic Letters, 10(14), 3161-3164 (2008)
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