Influence of solvent on reduction mechanism of 3-nitrobenzyl chloride was investigated by cyclic voltammetry and controlled potential bulk electrolysis[1].
Application
3-Nitrobenzyl chloride was used in the synthesis of 8-chloropurine[2].
Journal of medicinal chemistry, 33(1), 196-202 (1990-01-01)
A series of 8-substituted analogues of 9-(3-aminobenzyl)-6-(dimethylamino)-9H-purine (8) were synthesized and tested for their ability to bind to the benzodiazepine receptor (BZR) in rat brain tissue. The most active compound was the 8-bromo-9-(3-formamidobenzyl) analogue 16 (IC50 = 0.011 microM), which
Solvent effects on the reduction mechanism of 3-chloroanthracene, 3-nitrobenzyl chloride and 3-chloroacetophenone.
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