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Sigma-Aldrich

Methanesulfonyl fluoride

98%

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About This Item

Linear Formula:
CH3SO2F
CAS Number:
558-25-8
Molecular Weight:
98.10
EC Number:
209-192-2
MDL number:
MFCD00007423
UNSPSC Code:
12352100
PubChem Substance ID:
24850783

assay

98%

reaction suitability

reaction type: click chemistry

bp

123-124 °C (lit.)

density

1.427 g/mL at 25 °C (lit.)

SMILES string

CS(F)(=O)=O

InChI

1S/CH3FO2S/c1-5(2,3)4/h1H3

InChI key

KNWQLFOXPQZGPX-UHFFFAOYSA-N

General description

Methanesulfonyl fluoride is an anticholinesterase (antiChEs), used to treat Alzheimer′s disease. It is a thrombin inhibitor.

accessory

Product No.
Description
Pricing

pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Skin Corr. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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M Zorko et al.
Biochemical pharmacology, 35(14), 2287-2296 (1986-07-15)
The binding of D-tubocurarine (TC) to acetylcholinesterase (AChE) was studied using different methods of enzyme kinetics. The main results are as follows. TC reversibly inhibits the hydrolysis of different substrates of AChE with three different inhibition constants (Ki1 = 7.0
D H Malin et al.
Neurobiology of aging, 12(2), 181-183 (1991-03-01)
In previous studies, 18-month-old rats have shown no significant retention 24 hours after the single acquisition trial in a one-trial discriminative reward learning task. In the present study, ten 18-month-old rats pretreated with 0.5 mg/kg MSF IP showed significantly better
P Masson et al.
Biochimica et biophysica acta, 869(3), 304-313 (1986-02-14)
In order to determine whether a structural modification at the active center of cholinesterase may alter the conformational stability of the enzyme we compared the urea-induced unfolding of the tetrameric form of non-inhibited and irreversibly inhibited human plasma cholinesterase (acylcholine
D H Malin et al.
Neurobiology of aging, 14(4), 393-395 (1993-07-01)
Aged (24-month-old) rats were treated chronically with methanesulfonyl fluoride (MSF), an acetylcholinesterase (AChE) inhibitor with selectivity for central nervous system AChE, or with injection vehicle alone. Twelve 0.22 mg/kg IP injections were given over 4 weeks. MSF rats showed significantly
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