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About This Item
Linear Formula:
HC6F4NH2
CAS Number:
Molecular Weight:
165.09
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
Recommended Products
assay
98%
bp
78 °C/13 mmHg (lit.)
mp
27-29 °C (lit.)
SMILES string
Nc1cc(F)c(F)c(F)c1F
InChI
1S/C6H3F4N/c7-2-1-3(11)5(9)6(10)4(2)8/h1H,11H2
InChI key
BEECAQIHCYTZHC-UHFFFAOYSA-N
General description
2,3,4,5-Tetrafluoroaniline reacts with glycerol, crotonaldehyde, and methyl vinyl ketone by Skraup reaction to form 5,6,7,8-Tetrafluoroquinoline and 2- and 4-methyl-5,6,7,8-tetrafluoroquinoline, respectively.
Application
2,3,4,5-Tetrafluoroaniline can be used in the synthesis of polyfluorinated quinolines.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
174.2 °F - closed cup
flash_point_c
79 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Partially fluorinated heterocyclic compounds. Part I. The preparation of some tetra-and tri-fluoroquinolines, and some reactions of 5, 6, 7, 8-tetrafluoroquinoline.
Brooke GM, et al.
J. Chem. Soc. Sect. C, 215-218 (1966)
N-Acetylation as a Means to Activate Polyfluoroarylamines for Selective ortho-Hydrodefluorination by Zinc in Aqueous Ammonia: A Concise Route to Polyfluorobenzo Azaheterocycles.
Laev SS, et al.
European Journal of Organic Chemistry, 2007(2), 306-316 (2007)
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