The SPME-LC fiber probes are intended as single-use devices for the extraction of small molecules out of a fluid followed by solvent desorption and LC analysis.
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Journal of pharmaceutical and biomedical analysis, 54(5), 926-950 (2011-01-05)
Biomedical analyses of drugs, metabolites, poisons, environmental and occupational pollutants, disease biomarkers and endogenous substances in body fluids and tissues are important in the development of new drugs, therapeutic monitoring, forensic toxicology, patient diagnosis, and biomonitoring of human exposure to
Metabolic Profiling of Plasma from Cardiac Surgical Patients Concurrently Administered with Tranexamic Acid: DI-SPME?LC?MS Analysis
Bojko, B., et al.
Journal of Pharmaceutical Analysis, 4 (1), 6-13 (2014)
Solid-Phase Microextraction. How Far are We from Clinical Practice?
Bojko, B., et al.
TrAC, Trends in Analytical Chemistry, 30 (9), 1505-1512 (2011)
Journal of pharmaceutical and biomedical analysis, 47(4-5), 907-912 (2008-05-13)
Pharmacokinetic (PK) studies in rats typically involve removal of serial blood samples following dosing. This research illustrates the development of a fast in vivo microextraction technique that has the potential to partly replace current sampling techniques based on blood draws
Solid phase microextraction (SPME) has experienced rapid development and growth in number of application areas since its inception over 20 years ago. It has had a major impact on sampling and sample preparation practices in chemical analysis, bioanalysis, food and
Accurate protein binding affinities were measured using bioSPME more rapidly than membrane dialysis (RED) techniques. Binding affinities correlated to the reference values.
A demonstration of the use of innovative BioSPME fibers for the selective extraction of drugs and polar metbolites from biological matrices.
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